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Titolo:
Subchronic inhalation toxicity of the chlorinated propane 1,1,1,3,3,3-hexachloropropane (HCC-230fa)
Autore:
Bamberger, JR; Ladics, GS; Hurtt, ME; Swanson, MS; Brock, WJ;
Indirizzi:
Dupont Co, Haskell Lab Toxicol & Ind Med, Newark, DE 19714 USA Dupont Co Newark DE USA 19714 Lab Toxicol & Ind Med, Newark, DE 19714 USA Pfizer Inc, Div Cent Res, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 er Inc, Div Cent Res, Groton, CT 06340 USA Unilever Res, SEAC Toxicol Unit, Edgewater, NJ 07020 USA Unilever Res Edgewater NJ USA 07020 Toxicol Unit, Edgewater, NJ 07020 USA Vulcan Chem, Birmingham, AL 35238 USA Vulcan Chem Birmingham AL USA 35238Vulcan Chem, Birmingham, AL 35238 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 62, anno: 2001,
pagine: 155 - 165
SICI:
1096-6080(200107)62:1<155:SITOTC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS; MICE; 1,2-DIBROMO-3-CHLOROPROPANE; DISPOSITION; METABOLISM;
Keywords:
halogenated hydrocarbons; chlorinated alkanes; inhalation; repeated exposure; immunotoxicity; hepatotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Brock, WJ Dupont Co, Haskell Lab Toxicol & Ind Med, Newark, DE 19714 USA Dupont Co Newark DE USA 19714 l & Ind Med, Newark, DE 19714 USA
Citazione:
J.R. Bamberger et al., "Subchronic inhalation toxicity of the chlorinated propane 1,1,1,3,3,3-hexachloropropane (HCC-230fa)", TOXICOL SCI, 62(1), 2001, pp. 155-165

Abstract

Male and female rats were exposed by inhalation (whole body) to HCC-230fa (1,1,1,3,3,3-hexachloropropane) for 6 h/day, 5 days/ week over a 15-week period, Concentrations of 0, 0.50, 2.5, and 25 ppm were studied. A total of eight groups/sex were exposed. Four groups of male and four groups of femalerats were used to measure clinical signs and growth, clinical pathology, and tissue pathology. The remaining four groups of male rats were used for immunotoxicological and sperm assessment evaluations, and the remaining fourgroups of female rats were used for immunotoxicological evaluation. Following the exposure period, surviving male rats were kept for a 1- or 3-month recovery period. Male and female rats exposed to 25 ppm had lower mean bodyweights, mean body weight gains, and food consumption during the exposure period. Male and female rats exposed to 25 ppm and sacrificed immediately after the exposure period had minimally decreased total leukocyte and lymphocyte counts. These changes were considered to be marginally adverse. Pathologic examination revealed hepatocellular hypertrophy in 0-day recovery males and an increased incidence and/or severity in chronic progressive nephropathy in 0-day, 1-month recovery, and 1-month recovery males at 25 ppm. No other pathological changes, including the testis, epididymis, and other accessory sex organs, were noted in rats during the study. Evaluation of sperm parameters at the end of the exposure period showed statistically significant decreases in epididymal sperm number per cauda epididymis, percent motile sperm, and percent normal sperm morphology at 25 ppm. The biological significance of the slight changes observed in the sperm parameters in the absence of histopathological changes is unclear. After a 1-month recovery period, no biologically significant differences in sperm parameters were noted at 25 ppm compared with controls. Exposure to HCC-230fa did not significantly alter the primary humoral immune response to sheep red blood cell (SRBC),Under the conditions of this study, the no-observed-adverse-effect level (NOAEL) was considered to be 2.5 ppm.

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Documento generato il 31/03/20 alle ore 19:28:29