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Titolo:
In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat
Autore:
Lewis, BC; Hudgins, S; Lewis, A; Schorr, K; Sommer, R; Peterson, RE; Flaws, JA; Furth, PA;
Indirizzi:
Univ Maryland, Sch Med, Inst Human Virol, Div Infect Dis,Dept Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 is,Dept Med, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Prevent Med, Baltimore, MD 21201 USA Univ Maryland, Sch Med, Dept Physiol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 ept Physiol, Baltimore, MD 21201 USA Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 sin, Sch Pharm, Madison, WI 53706 USA Univ Wisconsin, Ctr Environm Toxicol, Madison, WI 53706 USA Univ Wisconsin Madison WI USA 53706 vironm Toxicol, Madison, WI 53706 USA
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 62, anno: 2001,
pagine: 46 - 53
SICI:
1096-6080(200107)62:1<46:IUALTW>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-UTERO; GENE-EXPRESSION; RECEPTOR-ALPHA; PROSTATE DEVELOPMENT; HOLTZMAN RATS; CROSS-TALK; EXPOSURE; TCDD; GROWTH; CANCER;
Keywords:
TCDD; estrogen receptor alpha; mammary gland; in utero and lactational exposure; differentiation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Lewis, BC Univ Maryland, Sch Med, Inst Human Virol, Div Infect Dis,Dept Med, 725 W Lombard St,Room N545, Baltimore, MD 21201 USA Univ Maryland 725 W Lombard St,Room N545 Baltimore MD USA 21201
Citazione:
B.C. Lewis et al., "In utero and lactational treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin impairs mammary gland differentiation but does not block the response to exogenous estrogen in the postpubertal female rat", TOXICOL SCI, 62(1), 2001, pp. 46-53

Abstract

These experiments tested whether in utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters mammary gland differentiation, estrogen receptor alpha (ER alpha) expression levels, or the response to estrogen in the female postpubertal rat mammary gland. Pregnant Holtzman rats were administered a single oral dose of 1 mug/kg TCDD or vehicle on gestation-day 15, Exposed and non-exposed female offspring were weaned on postnatal day 21 and ovariectomized at 9 weeks of age. Two weeks later, both TCDD and control animals were divided into 3 groups, receiving treatment with placebo, 0.025, or 0.1 mg 17 beta -estradiol pellet implants. After 48 h, mammary tissue was removed for analysis following euthanasia. TCDD-exposed mammary glands demonstrated impaired differentiation as measured by the distribution of terminal ductal structures and increased expression levels of ER alpha, The response to exogenous estrogen was tested in TCDD-exposed animals and compared to control nonexposed animals. Estrogen stimulation of theTCDD-exposed glands induced progesterone receptor expression and mammary gland differentiation as measured by a shift in distribution from terminal end buds and terminal ducts to Types I and II lobules, Control glands were better differentiated at baseline and did not exhibit any significant changes in the distribution of terminal ductal structures following estrogen stimulation. The increase in progesterone receptor-expression levels by exogenous estrogen in control glands was similar to the TCDD-exposed glands. Theseexperiments demonstrate that in utero and lactational exposures to TCDD impair mammary gland differentiation but that TCDD-exposed mammary glands retain the ability to differentiate in response to estrogen.

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Documento generato il 23/01/21 alle ore 10:04:26