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Titolo:
Thyroid stimulating hormone downregulates vascular endothelial growth factor expression in FRTL-5 cells
Autore:
Miyagi, E; Katoh, R; Li, X; Lu, S; Suzuki, K; Maeda, S; Shibuya, M; Kawaoi, A;
Indirizzi:
Yamanashi Med Univ, Sch Med, Dept Pathol, Tamaho, Yamanashi 4093898, JapanYamanashi Med Univ Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan Washington Hosp Ctr, Mol Endocrinol Lab, MedStar Res Inst, Washington, DC USA Washington Hosp Ctr Washington DC USA dStar Res Inst, Washington, DC USA Yamanashi Med Univ, Sch Med, Dept Biochem, Tamaho, Yamanashi 4093898, Japan Yamanashi Med Univ Tamaho Yamanashi Japan 4093898 amanashi 4093898, Japan Univ Tokyo, Dept Genet, Inst Med Sci, Tokyo, Japan Univ Tokyo Tokyo Japan iv Tokyo, Dept Genet, Inst Med Sci, Tokyo, Japan
Titolo Testata:
THYROID
fascicolo: 6, volume: 11, anno: 2001,
pagine: 539 - 543
SICI:
1050-7256(200106)11:6<539:TSHDVE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; PERMEABILITY FACTOR; IN-VIVO; FOLLICULAR THYROGLOBULIN; IDENTIFICATION; ANGIOGENESIS; GENE; MITOGEN; MECHANISMS; PROMOTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Katoh, R Yamanashi Med Univ, Sch Med, Dept Pathol, 1110 Shimokato, Tamaho,Yamanashi 4093898, Japan Yamanashi Med Univ 1110 Shimokato Tamaho Yamanashi Japan 4093898
Citazione:
E. Miyagi et al., "Thyroid stimulating hormone downregulates vascular endothelial growth factor expression in FRTL-5 cells", THYROID, 11(6), 2001, pp. 539-543

Abstract

We studied the regulation of the expression of vascular endothelial growthfactor (VEGF) by TSH in monolayer cultures of rat thyroid FRTL-5 cell lines. The VEGF mRNA synthesis was significantly inhibited by TSH as well as diloutyryl cyclic adenosine monophosphate (cAMP) in a dose-dependent manner in FRTL-5 cells. This observation is contrary to previously published results using the thyroid follicular culture system. Our results suggest that thedirect effect of TSH/cAMP is to inhibit the VEGF synthesis in monolayer cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:04:42