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Titolo:
Regulation of PAI-1 concentration in platelets by systemic administration of antisense oligonucleotides to rats
Autore:
Pawlowska, Z; Chabielska, E; Kobylanska, A; Maciaszek, A; Swiatkowska, M; Buczko, W; Stec, WJ; Cierniewski, CS;
Indirizzi:
Med Univ Lodz, Dept Biophys, PL-90131 Lodz, Poland Med Univ Lodz Lodz Poland PL-90131 , Dept Biophys, PL-90131 Lodz, Poland Med Univ Bialystok, Dept Pharmacodynam, Bialystok, Poland Med Univ Bialystok Bialystok Poland pt Pharmacodynam, Bialystok, Poland Polish Acad Sci, Dept Bioorgan Chem, Lodz, Poland Polish Acad Sci Lodz Poland Acad Sci, Dept Bioorgan Chem, Lodz, Poland Polish Acad Sci, Ctr Mol & Macromol Studies, Lodz, Poland Polish Acad SciLodz Poland i, Ctr Mol & Macromol Studies, Lodz, Poland
Titolo Testata:
THROMBOSIS AND HAEMOSTASIS
fascicolo: 6, volume: 85, anno: 2001,
pagine: 1086 - 1089
SICI:
0340-6245(200106)85:6<1086:ROPCIP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMINOGEN-ACTIVATOR INHIBITOR-1; IN-VITRO; EXPERIMENTAL THROMBOSIS; ENDOTHELIAL-CELLS; CLOT LYSIS; FIBRINOLYSIS; THROMBOLYSIS; RELEASE; OLIGODEOXYRIBONUCLEOTIDES; RESISTANCE;
Keywords:
PAI-1; antisense oligonucleotides; blood platelets;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Cierniewski, CS Med Univ Lodz, Dept Biophys, 3 Lindley St, PL-90131 Lodz, Poland Med Univ Lodz 3 Lindley St Lodz Poland PL-90131 z, Poland
Citazione:
Z. Pawlowska et al., "Regulation of PAI-1 concentration in platelets by systemic administration of antisense oligonucleotides to rats", THROMB HAEM, 85(6), 2001, pp. 1086-1089

Abstract

In this report we tested the effect of oligodeoxyribonucleotides antisenseto PAI-1 mRNA administered into rats on PAI-1 concentration in platelets. Low doses of the antisense: oligonucleotide (MPO-16R) reduced PAI-1 activity, both in rat blood plasma and platelet lysates by 20.5% and 28.7%. respectively. There was no change in platelet count after treatment with MPO-16R but treated platelets showed lower aggregability as compared with controls (37 +/- 13% and 54 +/- 12%, respectively). In an experimental model of rat arterial thrombosis, low doses of MPO-16R caused a significant delay in theocclusion time (31.8%). These data further support for the role of PAI-1 as a major determinant of arterial thrombolysis resistance and for the firsttime demonstrate the possibility of reduction of platelet PAI-1 concentration by antisense approach.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:24:02