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Titolo:
Sampling local respiratory tract sites for inflammation
Autore:
Reynolds, HY;
Indirizzi:
Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 rshey Med Ctr, Hershey, PA 17033 USA
Titolo Testata:
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
fascicolo: 2, volume: 18, anno: 2001,
pagine: 138 - 148
SICI:
1124-0490(200106)18:2<138:SLRTSF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PULMONARY FIBROSIS; BRONCHOALVEOLAR LAVAGE FLUIDS; HUMAN ALVEOLAR MACROPHAGES; INTERSTITIAL LUNG-DISEASE; AIRWAY INFLAMMATION; HYPERSENSITIVITY PNEUMONITIS; COMPUTED-TOMOGRAPHY; CHEMOTACTIC FACTORS; CIGARETTE-SMOKING; CYTOKINE RELEASE;
Keywords:
bronchoalveolar lavage; bronchial lavage; nasal lavage; inflammation;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Reynolds, HY Penn State Univ, Milton S Hershey Med Ctr, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 , Hershey, PA 17033 USA
Citazione:
H.Y. Reynolds, "Sampling local respiratory tract sites for inflammation", SARCO VASC, 18(2), 2001, pp. 138-148

Abstract

Although host defense mechanisms protect the health of the respiratory tract, deficiencies or excessive host responses such as inflammation can create sine-nasal and pulmonary illnesses. Analysis of expectorated secretions (sputum) is traditional, but selective site specific samples (surface washing) seem more applicable for studying illnesses such as rhinitis, bronchitis, or aveolitis, Regional samples should contain representative components (cells and proteins) that ideally reflect changes in adjacent tissue; however, biopsy of contiguous mucosa and lung parenchyma is required fur a comprehensive analysis that can link surface samples and tissue pathology. Clinical strategies must be flexible so that maximal information about the host can be obtained through investigation of healthy normals, volunteer-patientswith latent illness that can be induced locally and observed in situ, and patients with active illness. Implicit in studying inflammation is the adaptation of new analytic methods to surface or topical samples such as nasal,bronchial and bronchoalveolar lavage (BALF). More correlations between respective components in nasal fluids, bronchial and BAL specimens seem indicated, so that more readily available samples can be used for clinical monitoring, Moreover, further correlations between bronchial and BAL cells and immunohistochemical analysis of tissue for cells are needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:49:54