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Titolo:
PCBs and neurodevelopmental effects in Michigan children: An evaluation ofexposure and dose characterization
Autore:
Schell, JD; Budinsky, RA; Wernke, MJ;
Indirizzi:
BBL Inc, BBL Sci, Tallahassee, FL 32301 USA BBL Inc Tallahassee FL USA 32301 Inc, BBL Sci, Tallahassee, FL 32301 USA
Titolo Testata:
REGULATORY TOXICOLOGY AND PHARMACOLOGY
fascicolo: 3, volume: 33, anno: 2001,
pagine: 300 - 312
SICI:
0273-2300(200106)33:3<300:PANEIM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYCHLORINATED-BIPHENYLS PCBS; GESTATIONAL-AGE; BIRTH-WEIGHT; GREAT-LAKES; PRENATAL EXPOSURE; FISH CONSUMPTION; YOUNG-CHILDREN; LEAD-EXPOSURE; DDT LEVELS; HUMANS;
Keywords:
PCBs; neurodevelopmental effects; fish consumption; exposure estimates;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Schell, JD BBL Inc, BBL Sci, 1203 Governors Sq Blvd,6th Floor, Tallahassee, FL 32301 USA BBL Inc 1203 Governors Sq Blvd,6th Floor Tallahassee FL USA 32301
Citazione:
J.D. Schell et al., "PCBs and neurodevelopmental effects in Michigan children: An evaluation ofexposure and dose characterization", REGUL TOX P, 33(3), 2001, pp. 300-312

Abstract

Despite the fact that PCB levels in the general environment have continuedto decline over the past decade, concern for potential neurodevelopmental deficits from in utero exposure to these compounds remains unabated. In fact, some regulatory and scientific bodies have concluded that the evidence suggesting that prenatal exposure to PCBs may lead to neurodevelopmental deficits is one of the greatest public health concerns surrounding PCBs. The primary basis for the concern that low-level in utero exposure to PCBs causes neurodevelopmental deficits in children is a series of reports on a cohort of Michigan children presumably exposed to PCBs as a result of their mother's consumption of Great Lakes fish. These children, known collectively asthe Jacobson cohort, have been followed from birth to 11 years of age. Theinvestigators following these children concluded that they have demonstrated persistent neurodevelopmental effects in this cohort attributable solelyto PCBs. However, a detailed analysis of the cohort's exposure characterization, particularly in the initial reports, reveals considerable uncertainty as to the actual exposure status of mothers characterized as "fish eaters" and their offspring. Failure to adequately characterize the PCB exposure of these mothers, or their children, precludes any causal association between in utero exposure to PCBs and neurodevelopmental deficits. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:11:37