Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dyslipidaemia in patients with malignant-phase hypertension
Autore:
Edmunds, E; Landray, MJ; Li-Saw-Hee, FL; Hughes, BA; Beevers, DG; Lip, GYH;
Indirizzi:
Univ Birmingham, Div Med Sci, Birmingham B15 2TT, W Midlands, England UnivBirmingham Birmingham W Midlands England B15 2TT W Midlands, England City Hosp, Birmingham, W Midlands, England City Hosp Birmingham W Midlands England Birmingham, W Midlands, England Queen Elizabeth Hosp, Birmingham B15 2TH, W Midlands, England Queen Elizabeth Hosp Birmingham W Midlands England B15 2TH lands, England
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 6, volume: 94, anno: 2001,
pagine: 327 - 332
SICI:
1460-2725(200106)94:6<327:DIPWMH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN SUBFRACTIONS; HEART-DISEASE; CHOLESTEROL; RISK; MEN; ASSOCIATION; PARTICLES; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Lip, GYH City Hosp NHS Trust, Thrombosis & Basc Biol Unit, Dudley Rd, Birmingham B18 7QH, W Midlands, England City Hosp NHS Trust Dudley Rd Birmingham W Midlands England B18 7QH
Citazione:
E. Edmunds et al., "Dyslipidaemia in patients with malignant-phase hypertension", QJM-MON J A, 94(6), 2001, pp. 327-332

Abstract

Low-density lipoprotein (LDL) consists of a heterogeneous group of particles of differing size, density and electrophoretic mobility, smaller particles being more atherogenic. A high proportion of small LDL particles is an independent risk factor for cardiovascular disease. We hypothesized that patients with malignant phase hypertension (MHT), the most severe form of hypertension, would demonstrate a more atherogenic LDL subfraction profile thaneither non-malignant hypertension (NMHT) or normotensive controls. We compared 16 patients with MHT to 41 patients with untreated NMHT and 45 normotensive controls. LDL subfraction profile was measured by disc polyacrylamidegel electrophoresis using a validated scoring system to calculate the meansize (locus) and heterogeneity (spread) of LDL subfraction mobilities. A higher LDL locus indicates a greater proportion of small LDL subfractions. LDL cholesterol levels were similar in all three groups (p=0.23). High-density lipoprotein cholesterol (HDL-C) levels were significantly lower (p < 0.001) and serum triglyceride concentrations significantly higher (p=0.02) in the MHT group, compared to normotensive controls. LDL locus was greater in the NMHT group than in the normotensive controls and intermediate in the MHT group (P=0.008). There was no significant difference in LDL spread (p=0.26). Serum triglyceride concentrations were not significantly higher after adjusting for confounding variables. MHT is associated with an abnormal lipid profile, characterized by low HDL-cholesterol concentration. This dyslipidaemia may be partly responsible for the vascular complications and the poor prognosis of these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:59:29