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Titolo:
Activation of the endothelin system in insulin resistance
Autore:
Irving, RJ; Noon, JP; Watt, GCM; Webb, DJ; Walker, BR;
Indirizzi:
Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH4 2XU Midlothian, Scotland Univ Glasgow, Dept Gen Practice, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland
Titolo Testata:
QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS
fascicolo: 6, volume: 94, anno: 2001,
pagine: 321 - 326
SICI:
1460-2725(200106)94:6<321:AOTESI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH BLOOD-PRESSURE; ESSENTIAL-HYPERTENSION; PLASMA ENDOTHELIN-1; BIG ENDOTHELIN-1; ELEVATED PLASMA; YOUNG-ADULTS; IMMUNOREACTIVITY; PREDISPOSITION; MEN; ABNORMALITIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, BR Univ Edinburgh, Western Gen Hosp, Dept Med Sci, Crewe Rd S, Edinburgh EH4 2XU, Midlothian, Scotland Univ Edinburgh Crewe Rd S Edinburgh Midlothian Scotland EH4 2XU
Citazione:
R.J. Irving et al., "Activation of the endothelin system in insulin resistance", QJM-MON J A, 94(6), 2001, pp. 321-326

Abstract

Endothelin-1, released from the vascular endothelium after cleavage from big endothelin-1, is a potent paracrine vasoconstrictor peptide. Small studies suggest that circulating levels of endothelin-7 are elevated in subjectswith cardiovascular risk factors. Big endothelin-1 levels may better reflect endothelin-1 generation. We examined retationships between plasma endothelin-1, plasma big endothelin-1, and predisposition to hypertension or other cardiovascular risk factors associated with insulin resistance in a largegroup of healthy young men. We recruited 96 healthy men aged 24-33 years from a cohort of 864 young men and women in whom predisposition to hypertension had been defined on the basis of their own blood pressure and the bloodpressures of their parents. They attended after an overnight fast for measurement of blood pressure, anthropometry, and plasma lipids, insulin, glucose, endothelin-1 and big endothelin-1. Plasma endothelin-1 and big endothelin-1 levels did not correlate with blood pressure (r = 0.09, -0.002 respectively) and were not influenced by parental blood pressure. Higher plasma endothelin-1 levels were associated with higher body mass index (r = 0.29, p < 0.005), and higher plasma insulin (r = 0.21, p < 0.05). Higher plasma bigendothelin-1 levels were associated with insulin resistance, as assessed by the Homeostasis Model of Assessment resistance index (r = 0.30, p < 0.005). Endothelin-1 levels are not related to blood pressure, but are higher inhealthy young men with insulin resistance and obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 10:46:43