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Titolo:
Chronic stress differentially regulates glucocorticoid negative feedback response in rats
Autore:
Mizoguchi, K; Yuzurihara, M; Ishige, A; Sasaki, H; Chui, DH; Tabira, T;
Indirizzi:
Tsumura & Co, Cent Res Labs, Dept Pharmacol, Ami, Ibaraki 3001192, Japan Tsumura & Co Ami Ibaraki Japan 3001192 macol, Ami, Ibaraki 3001192, Japan NCNP, Natl Inst Neurosci, Dept Demyelinating Dis & Aging, Kodaira, Tokyo 1878502, Japan NCNP Kodaira Tokyo Japan 1878502 s & Aging, Kodaira, Tokyo 1878502, Japan
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 5, volume: 26, anno: 2001,
pagine: 443 - 459
SICI:
0306-4530(200107)26:5<443:CSDRGN>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEXAMETHASONE SUPPRESSION TEST; PITUITARY-ADRENAL AXIS; IMMEDIATE-EARLY GENES; PREFRONTAL CORTEX; RECEPTOR IMMUNOREACTIVITY; MAJOR DEPRESSION; DNA-BINDING; C-JUN; BRAIN; CORTICOSTERONE;
Keywords:
chronic stress; corticosterone; dexamethasone suppression test; glucocorticoid negative feedback; glucocorticoid receptor; hippocampus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Mizoguchi, K Tsumura & Co, Cent Res Labs, Dept Pharmacol, 3586 Yoshiwara, Ami, Ibaraki 3001192, Japan Tsumura & Co 3586 Yoshiwara Ami Ibaraki Japan 3001192 , Japan
Citazione:
K. Mizoguchi et al., "Chronic stress differentially regulates glucocorticoid negative feedback response in rats", PSYCHONEURO, 26(5), 2001, pp. 443-459

Abstract

Exposure to chronic stress is thought to play an important role in the etiology of depression. In this disorder, a disrupted negative feedback response to exogenous glucocorticoids on cortisol secretion has been indicated. However, the regulation of glucocorticoid negative feedback by chronic stress is not fully understood. In the present study, we investigated the effects of chronic stress administered by water immersion and restraint (2 h/day)for four weeks on the glucocorticoid feedback in rats. In the acutely (one-time) stressed rats, the basal plasma corticosterone (CORT) level was markedly elevated, remained at high levels for 5 h after the termination of stress, and then decreased. In the chronically stressed rats, the CORT level was initially elevated similarly, but rapidly decreased at 2 h. In the dexamethasone (DEX) suppression test, the peak CORT level in response to stress was not suppressed by DEX in the acutely stressed rats, but was significantly suppressed in the chronically stressed rats. In contrast, the suppressive effects of DEX on the basal CORT secretion in naive rats were attenuated in the chronically stressed rats. In the chronically stressed hippocampus, which plays an important role in the regulation of the glucocorticoid feedback response, the binding of [H-3]DEX was decreased and the increased response of activator protein-1 induced by acute stress was abolished. These results suggest that chronic stress induces a hypersuppressive state for induced CORT secretion in response to acute stress, which is caused by partial habituation, coping, and adaptation to the stressor, whereas it induces a hyposuppressive state for the basal CORT secretion, which is caused by glucocorticoid receptor downregulation. These mechanisms may be involved in the stress-induced neural abnormalities observed in depression. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 14:14:51