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Titolo:
Effects of anesthesia on functional activation of cerebral blood flow and metabolism
Autore:
Nakao, Y; Itoh, Y; Kuang, TY; Cook, M; Jehle, J; Sokoloff, L;
Indirizzi:
NIMH, Cerebral Metab Lab, NIH, Bethesda, MD 20892 USA NIMH Bethesda MD USA 20892 erebral Metab Lab, NIH, Bethesda, MD 20892 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 13, volume: 98, anno: 2001,
pagine: 7593 - 7598
SICI:
0027-8424(20010619)98:13<7593:EOAOFA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; GLUCOSE-UTILIZATION; SOMATOSENSORY STIMULATION; NEURONAL MESSENGER; RAT; INHIBITION; BRAIN; CHLORALOSE; GLUTAMATE; CORTEX;
Keywords:
whisker-to-barrel cortex pathway; cerebral glucose utilization; deoxy[C-14]glucose; functional brain imaging; iodo[C-14]antipyrine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Sokoloff, L NIMH, Cerebral Metab Lab, NIH, Bldg 36,Room 1A-07,36 Convent Dr MSC 4030, Bethesda, MD 20892 USA NIMH Bldg 36,Room 1A-07,36 Convent Dr MSC 4030 Bethesda MD USA 20892
Citazione:
Y. Nakao et al., "Effects of anesthesia on functional activation of cerebral blood flow and metabolism", P NAS US, 98(13), 2001, pp. 7593-7598

Abstract

Functional brain mapping based on changes in local cerebral blood flow (ICBF) or glucose utilization (ICMRglc) induced by functional activation is generally carried out in animals under anesthesia, usually alpha -chloralose because of its lesser effects on cardiovascular, respiratory, and reflex functions. Results of studies on the role of nitric oxide (NO) in the mechanism of functional activation of ICBF have differed in unanesthetized and anesthetized animals. NO synthase inhibition markedly attenuates or eliminatesthe ICBF responses in anesthetized animals but not in unanesthetized animals. The present study examines in conscious rats and rats anesthetized withcy-chloralose the effects of vibrissal stimulation on ICMRglc and ICBF in the whisker-to-barrel cortex pathway and on the effects of NO synthase inhibition with N-G-nitro-L-arginine methyl ester (L-NAME) on the magnitude of the responses. Anesthesia markedly reduced the ICBF and ICMRglc responses in the ventral posteromedial thalamic nucleus and barrel cortex but not in the spinal and principal trigeminal nuclei. L-NAME did not alter the ICBF responses in any of the structures of the pathway in the unanesthetized rats and also not in the trigeminal nuclei of the anesthetized rats. In the thalamus and sensory cortex of the anesthetized rats, where the ICBF responses to stimulation had already been drastically diminished by the anesthesia, L-NAME treatment resulted in loss of statistically significant activation ofICBF by vibrissal stimulation. These results indicate that NO does not mediate functional activation of ICBF under physiological conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 23:14:06