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Titolo:
Identification and characterization of a melanin-concentrating hormone receptor
Autore:
An, SZ; Cutler, G; Zhao, JJ; Huang, SG; Tian, H; Li, WB; Liang, LM; Rich, M; Bakleh, A; Du, J; Chen, JL; Dai, K;
Indirizzi:
Tularik Inc, S San Francisco, CA 94080 USA Tularik Inc S San Francisco CAUSA 94080 c, S San Francisco, CA 94080 USA
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 13, volume: 98, anno: 2001,
pagine: 7576 - 7581
SICI:
0027-8424(20010619)98:13<7576:IACOAM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-COUPLED RECEPTOR; ALPHA-MSH; RAT-BRAIN; MCH; SLC-1; LIGAND; CELLS; GENE; NEUROPEPTIDE; HYPOTHALAMUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Dai, K Tularik Inc, 2 Corp Dr, S San Francisco, CA 94080 USA Tularik Inc 2Corp Dr S San Francisco CA USA 94080 co, CA 94080 USA
Citazione:
S.Z. An et al., "Identification and characterization of a melanin-concentrating hormone receptor", P NAS US, 98(13), 2001, pp. 7576-7581

Abstract

Melanin-concentrating hormone (MCH), a neuropeptide expressed in central and peripheral nervous systems, plays an important role in the control of feeding behaviors and energy metabolism. An orphan G protein-coupled receptor(SLC-1/GPR24) has recently been identified as a receptor for MCH (MCHR1). We report here the identification and characterization of a G protein-coupled receptor as the MCH receptor subtype 2 (MCHR2). MCHR2 has higher proteinsequence homology to MCHR1 than any other G protein-coupled receptor. The expression of MCHR2 has been detected in many regions of the brain. In contrast to MCHR1. which is intronless in the coding region and is located at the chromosomal locus 22q13.3, the MCHR2 gene has multiple exons and is mapped to locus 6q21. MCHR2 is specifically activated by nanomolar concentrations of MCH, binds to MCH with high affinity, and signals through Gq protein. This discovery is important for a full understanding of MCH biology and the development of potential therapeutics for diseases involving MCH. including obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:15:32