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Titolo:
INTERFERON-GAMMA DEFICIENCY PREVENTS CORONARY ARTERIOSCLEROSIS BUT NOT MYOCARDIAL REJECTION IN TRANSPLANTED MOUSE HEARTS
Autore:
NAGANO H; MITCHELL RN; TAYLOR MK; HASEGAWA S; TILNEY NL; LIBBY P;
Indirizzi:
HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DEPT MED,DIV CARDIOVASC BOSTON MA 02115 HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DEPT MED,DIV CARDIOVASC BOSTON MA 02115 HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DEPT SURG BOSTON MA 02115 HARVARD UNIV,SCH MED,BRIGHAM & WOMENS HOSP,DEPT PATHOL BOSTON MA 02115
Titolo Testata:
The Journal of clinical investigation
fascicolo: 3, volume: 100, anno: 1997,
pagine: 550 - 557
SICI:
0021-9738(1997)100:3<550:IDPCAB>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CARDIAC ALLOGRAFT VASCULOPATHY; ENDOTHELIAL-CELL ADHESIVENESS; INVARIANT CHAIN GENE; MONOCLONAL-ANTIBODY; ADHESION MOLECULE-1; IFN-GAMMA; T-CELLS; DERMAL FIBROBLASTS; IMMUNE INTERFERON;
Keywords:
ARTERIOSCLEROSIS; CARDIAC TRANSPLANTATION; IFN-GAMMA KNOCKOUT MOUSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
H. Nagano et al., "INTERFERON-GAMMA DEFICIENCY PREVENTS CORONARY ARTERIOSCLEROSIS BUT NOT MYOCARDIAL REJECTION IN TRANSPLANTED MOUSE HEARTS", The Journal of clinical investigation, 100(3), 1997, pp. 550-557

Abstract

We have hypothesized that T cell cytokines participate in the pathogenesis of graft arterial disease (GAD). This study tested the consequences of IFN-gamma, deficiency on arterial and parenchymal pathology in murine cardiac allografts, Hearts from C-H-2(bm12)KhEg (bm12, H-2(bm12)) were transplanted into C57/B6 (B6, H-2(b)), wild-type, or B6 IFN-gamma-deficient (GKO) recipients after immunosuppression by treatment with anti-CD4 and anti-CD8 mAbs, In wild-type recipients, myocardial rejection peaked at 4 wk, (grade 2.1+/-0.3 out of 4, mean+/-SEM, n = 9), and by 8-12 wk evolved coronary arteriopathy. At 12 wk, the GAD score was 1.4+/-0.3, and the parenchymal rejection grade was 1.2+/-0.3 (n = 8), In GKO recipients of bm12 allografts, myocardial rejection persisted at 12 wk (grade 2.5+/-0.3, n = 6), but no GAD developed (score: 0.0/-0.0, n = 6, P < 0.01 vs. wild-type). Mice treated with anti-IFN-gamma mAbs showed similar results, Isografts generally showed no arterialchanges, In wild-type recipients? arterial and parenchymal cells showed increased MHC class II molecules, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 compared to normal or isografted hearts, The allografts in GKO recipients showed attenuated expression of these molecules (n = 6), Thus, development of GAD, but not parenchymal rejection, requires IFN-gamma. Reduced expression of MHC antigens and leukocyte adhesion molecules may contribute to the lack of coronary arteriopathy in hearts allografted into GKO mice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 09:46:43