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Titolo:
The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent
Autore:
Takahashi, T; Kamimura, A; Yokoo, Y; Honda, S; Watanabe, Y;
Indirizzi:
Kyowa Hakko Kogyo Co Ltd, Tsukuba Res Labs, Tsukuba, Ibaraki 3050841, Japan Kyowa Hakko Kogyo Co Ltd Tsukuba Ibaraki Japan 3050841 aki 3050841, Japan Kyowa Hakko Kogyo Co Ltd, Dept Dev, Div Biochem, Tokyo 1008185, Japan Kyowa Hakko Kogyo Co Ltd Tokyo Japan 1008185 ochem, Tokyo 1008185, Japan Watanabe Dermatol Clin, Shinjuku Ku, Tokyo 1600022, Japan Watanabe Dermatol Clin Tokyo Japan 1600022 juku Ku, Tokyo 1600022, Japan
Titolo Testata:
PHYTOTHERAPY RESEARCH
fascicolo: 4, volume: 15, anno: 2001,
pagine: 331 - 336
SICI:
0951-418X(200106)15:4<331:TFCTOT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MALE PATTERN BALDNESS; UNIT AREA TRICHOGRAM; CELLS IN-VITRO; ANDROGENETIC ALOPECIA; PROMOTE PROLIFERATION; MINOXIDIL; FOLLICLE; TANNINS; GROWTH; VIVO;
Keywords:
androgenetic alopecia; condensed tannin; external application; Malus pumila; proanthocyanidins; scalp;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, T Kyowa Hakko Kogyo Co Ltd, Tsukuba Res Labs, 2 Miyukigaoka, Tsukuba, Ibaraki 3050841, Japan Kyowa Hakko Kogyo Co Ltd 2 Miyukigaoka Tsukuba Ibaraki Japan 3050841
Citazione:
T. Takahashi et al., "The first clinical trial of topical application of procyanidin B-2 to investigate its potential as a hair growing agent", PHYTOTHER R, 15(4), 2001, pp. 331-336

Abstract

Procyanidin B-2 is a compound we have identified in apple which acts as a growth-promoting factor on murine hair epithelial cells. This report describes our investigation of the hair-growing effects of 1% procyanidin B-2 tonic after sequential use for 4 months, A double-blind clinical trial was performed, involving a total of 29 subjects (procyanidin B-2, 19 men; placebo,10 men), No adverse side effects were observed in either group. In the procyanidin B-2 group, 78.9% showed an increased mean value of hair diameter, whereas only 30.0% in the placebo group showed any increase (p < 0.02, Fisher's exact probability test). The increased ratio of hairs measuring more than 40 pm in diameter after 4 months of procyanidin B-2 treatment was significantly higher than that of the placebo controls (p < 0.05, two-sample t-test), The increase in number of total hairs in the designated scalp area (0.25 cm(2)) of procyanidin B-2 subjects after a 4 month trial was significantly greater than that of the placebo controls (procyanidin B-2, 3.67 +/- 4.09 (mean +/- SD)/0.25 cm(2); placebo, -2.54 +/- 4.00/0.25 cm(2); p < 0.001,two-sample t-test), Procyanidin B-2 therapy shows potential as a promisingcure for male pattern baldness, Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:57:01