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Titolo:
Travels in a world of small science
Autore:
Zelitch, I;
Indirizzi:
Connecticut Agr Expt Stn, Dept Biochem & Genet, New Haven, CT 06504 USA Connecticut Agr Expt Stn New Haven CT USA 06504 , New Haven, CT 06504 USA
Titolo Testata:
PHOTOSYNTHESIS RESEARCH
fascicolo: 3, volume: 67, anno: 2001,
pagine: 159 - 176
SICI:
0166-8595(2001)67:3<159:TIAWOS>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTILLUMINATION CO2 RELEASE; ENHANCED CATALASE ACTIVITY; O-2-RESISTANT PHOTOSYNTHESIS; TOBACCO PLANTS; INITIAL RATE; PHOTORESPIRATION; STOICHIOMETRY; LEAVES; MUTANT;
Keywords:
Robert H. Burris; carbon dioxide assimilation; catalase; glycolate; glyoxylate; James G. Horsfall; Severo Ochoa; photorespiration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Zelitch, I Connecticut Agr Expt Stn, Dept Biochem & Genet, POB 1106, New Haven, CT 06504 USA Connecticut Agr Expt Stn POB 1106 New Haven CT USA 0650404 USA
Citazione:
I. Zelitch, "Travels in a world of small science", PHOTOSYN R, 67(3), 2001, pp. 159-176

Abstract

As a boy, I read Sinclair Lewis's Arrowsmith and dreamed of doing researchof potential benefit to society. I describe the paths of my scientific career that followed. Several distinguished scientists served as my mentors and I present their profiles. Much of my career was in a small department at a small institution where independent researchers collaborated informally. I describe the unique method of carrying on research there. My curiosity about glycolate metabolism led to unraveling the enzymatic mechanism of the glycolate oxidase reaction and showing the importance of H2O2 as a byproduct. I discovered enzymes catalyzing the reduction of glyoxylate and hydroxypyruvate. I found alpha -hydroxysulfonates were useful competitive inhibitorsof glycolate oxidase. In a moment of revelation, I realized that glycolatemetabolism was an essential part of photorespiration, a process that lowers net photosynthesis in C-3 plants. I added inhibitors of glycolate oxidaseto leaves and showed: (1) glycolate was synthesized only in light as an early product of photosynthetic CO2 assimilation, (2) the rate of glycolate oxidation consumed a sizable fraction of net photosynthesis in C-3 but not in C-4 plants, and (3) that glycolate metabolism increased greatly at highertemperatures. For a while I studied the control of stomatal opening in leaves, and this led to the finding that potassium ions are a key solute in guard cells. I describe experiments that show that when photorespiration rates are high, as occurs at higher temperatures, genetically increasing leaf catalase activity reduces photorespiration and increases net photosythetic CO2 assimilation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 15:12:57