Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Factors associated with non-response in proton pump inhibitor users: a study of lansoprazole therapy
Autore:
Claessens, AAMC; Heerdink, ER; Lamers, CBHW; van Eijk, JTM; Leufkens, HGM;
Indirizzi:
Kendle, Utrecht, Netherlands Kendle Utrecht NetherlandsKendle, Utrecht, Netherlands Utrecht Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Pharmacotherapy, Utrecht, Netherlands Utrecht Inst Pharmaceut Sci Utrecht Netherlands y, Utrecht, Netherlands Leiden Univ, Med Ctr, Dept Gastroenterol & Hepatol, Leiden, Netherlands Leiden Univ Leiden Netherlands roenterol & Hepatol, Leiden, Netherlands Univ Maastricht, Fac Med, Dept Med Sociol, Maastricht, Netherlands Univ Maastricht Maastricht Netherlands Sociol, Maastricht, Netherlands
Titolo Testata:
PHARMACY WORLD & SCIENCE
fascicolo: 3, volume: 23, anno: 2001,
pagine: 107 - 110
SICI:
0928-1231(200106)23:3<107:FAWNIP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACID-RELATED DISORDERS; DOUBLE-BLIND; DUODENAL-ULCER; DOSE LANSOPRAZOLE; OMEPRAZOLE; PLACEBO; MULTICENTER; MANAGEMENT; RANITIDINE; RESISTANT;
Keywords:
effectiveness; daily practice; lansoprazole; non response; pharmacoepidemiology; proton pump inhibitor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Claessens, AAMC Kendle, Utrecht, Netherlands Kendle Utrecht NetherlandsKendle, Utrecht, Netherlands
Citazione:
A.A.M.C. Claessens et al., "Factors associated with non-response in proton pump inhibitor users: a study of lansoprazole therapy", PHARM WORLD, 23(3), 2001, pp. 107-110

Abstract

Background: Proton pump inhibitors (PPI) demonstrate high healing rates of85-98% in clinical trials. Due to the limited knowledge regarding responseand non-response to lansoprazole in daily practice and for the reason thatresistance to PPIs is scarce, we investigated factors possibly associated with non-response. Methods: Data were used from a prospective, open label, observational follow-up study in which 10,008 lansoprazole users were followed over time. Thestudy was designed according to the SAMM guidelines. A matched nested case-control design was used to compare non-responding (cases) and responding (controls) lansoprazole users. Non-response was defined as worsening or non-improvement of symptoms at the first evaluation after at least 8 weeks of use, response as disappearance or improvement of symptoms within 8 weeks of use. Controls were matched for the evaluating physician. Results: A total of 186 non-responders and 372 responders to PPI treatmentwere identified as cases and controls. Age of over 60 years, heavy smokingand previous use of PPIs were significantly more common in non-responding patients compared with responding patients. There were no differences foundbetween the reported diagnosis regarding response. Conclusion: In daily clinical practice, previous use of PPIs, heavy smoking and an age > 60 years were significantly associated with non-response to treatment with lansoprazole. Previous use of PPIs in non-responding patients might suggest resistance to PPIs. The knowledge that nonresponse drives non-response may encourage physicians to follow PPI users with previous PPI use more closely.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 09:16:36