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Titolo:
Perceptual and motor effects of morphine and buprenorphine in baboons
Autore:
Hienz, RD; Zarcone, TJ; Brady, JV;
Indirizzi:
Johns Hopkins Univ, Sch Med, Johns Hopkins Bayview Med Ctr, Baltimore, MD 21224 USA Johns Hopkins Univ Baltimore MD USA 21224 ed Ctr, Baltimore, MD 21224 USA Univ Kansas, Schiefelbusch Inst Life Span Studies, Lawrence, KS 66045 USA Univ Kansas Lawrence KS USA 66045 fe Span Studies, Lawrence, KS 66045 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1-2, volume: 69, anno: 2001,
pagine: 305 - 313
SICI:
0091-3057(200105/06)69:1-2<305:PAMEOM>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
NICTITATING-MEMBRANE RESPONSE; REACTION-TIMES; RHESUS-MONKEYS; NONHUMAN-PRIMATES; COCAINE; DISCRIMINATION; ACQUISITION; THRESHOLDS; DIAZEPAM; ACCURACY;
Keywords:
morphine; buprenorphine; auditory perception; discrimination; motor function; baboon; lever release;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Hienz, RD Johns Hopkins Univ, Sch Med, Johns Hopkins Bayview Med Ctr, 5510Nathan, Baltimore, MD 21224 USA Johns Hopkins Univ 5510 Nathan Baltimore MD USA 21224 21224 USA
Citazione:
R.D. Hienz et al., "Perceptual and motor effects of morphine and buprenorphine in baboons", PHARM BIO B, 69(1-2), 2001, pp. 305-313

Abstract

The effects of morphine and buprenorphine on auditory perceptual discriminations and response latency ("reaction time") in baboons are compared. The task employed synthetic human vowel sounds that art: readily generated in the laboratory, and closely approximate natural baboon "grunt" vocalizations[J. Acoust. Sec. Am. 101 (1997) 2951]. Baboons pressed a lever to produce one repeating "standard" vowel, and released the lever only when one of four other "comparison" vowels occasionally occurred in place of the standard vowel. The percentage of correct detections and median reaction time for each comparison were measured following intramuscular drug administrations ofmorphine (0.01-1.8 mg/kg) and buprenorphine (0.00032-0.032 mg/kg). Both morphine and buprenorphine impaired vowel discriminability, and greater impairments occurred for those comparison vowels that were mon similar in formant structure to the standard vowel. Morphine increased reaction time in all baboons, and buprenorphine increased reaction time in two of three baboons. Morphine's perceptual effects occurred within 20-30 min following drug administration; buprenorphine's perceptual effects occurred 50-100 min following drug administration. Morphine and buprenorphine did not differ in the time course of their maximal reaction time effects. The results demonstrate that both morphine and buprenorphine can impair auditory discriminations involving human vowel sounds in baboons, as well as lengthen reaction times tothe stimuli. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:24:53