Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of sertraline on regional neuropeptide concentrations in olfactorybulbectomized rats
Autore:
Bissette, G;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Human Behav, Jackson, MS 39216 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1-2, volume: 69, anno: 2001,
pagine: 269 - 281
SICI:
0091-3057(200105/06)69:1-2<269:EOSORN>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; FACTOR-LIKE IMMUNOREACTIVITY; REPEATED ELECTROCONVULSIVE SHOCK; MESSENGER-RNA LEVELS; OPEN-FIELD ACTIVITY; DEPRESSED-PATIENTS; CEREBROSPINAL-FLUID; SOMATOSTATIN LEVELS; HORMONE TRH; PARAVENTRICULAR NUCLEUS;
Keywords:
corticotropin-releasing hormone (CRF); thyrotropin-releasing hormone (TRH); somatotropin-release inhibiting factor (somatostatin, SRIF); corticosterone; locomotor activity; selective serotonin re-uptake inhibitor; antidepressant drugs; major depressive disorder;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Bissette, G Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, 2500 NState St, Jackson, MS 39216 USA Univ Mississippi 2500 N State St Jackson MS USA 39216 9216 USA
Citazione:
G. Bissette, "Effects of sertraline on regional neuropeptide concentrations in olfactorybulbectomized rats", PHARM BIO B, 69(1-2), 2001, pp. 269-281

Abstract

Corticotropin-releasing factor (CRF) and thyrotropin-releasing hormone (TRH) are two neuropeptides that exhibit increased cerebrospinal fluid (CSF) concentrations during major depressive episodes while somatostatin (somatotropin-release inhibiting factor, SRIF) is decreased. Clinical and basic research findings indicate that clinically effective antidepressant therapies often normalize the indicators of CRF and TRH hypersecretion as well as SRIFhyposecretion. The olfactory bulbectomized (OBX) rat is used to screen potential antidepressant drugs for clinical efficacy. This model requires chronic administration of the antidepressant drug to normalize OBX-induced behaviors such as increased locomotion in a novel environment. This report describes the regional brain concentration changes in CRF, TRH and SRIF produced by OBX and demonstrates the ability of the selective serotonin re-uptake inhibitor and antidepressant drug, sertraline ( 10 mg/kg), to normalize certain of these alterations in regional neuropeptide concentrations as well as normalizing OBX-induced increases in locomotor activity. OBX-induced increases in CRF concentrations in the hypothalamus and bed nucleus of the stria terminalis were specifically and significantly decreased by sertraline. OBX-induced increases in TRH concentrations in the hypothalamus were reversed by sertraline. The concentration of SRIF was significantly reduced by OBXin the anterior caudate and the piriform cortex, but sertraline reversed these changes only in the anterior caudate. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:03:04