Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA
Autore:
Rangisetty, JB; Bondarev, ML; Chang-Fong, J; Young, R; Glennon, RA;
Indirizzi:
Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1-2, volume: 69, anno: 2001,
pagine: 261 - 267
SICI:
0091-3057(200105/06)69:1-2<261:PGTTOI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS; MDA ANALOGS; PHENYLISOPROPYLAMINES; AMPHETAMINE; MDMA;
Keywords:
PMMA; amphetamine; MBDB; 3,4-DMA; MDMA; DOM; hallucinogens; designer drugs;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Glennon, RA Virginia Commonwealth Univ, Sch Pharm, Dept Med Chem, Box 980540, Richmond, VA 23298 USA Virginia Commonwealth Univ Box 980540 Richmond VA USA 23298 SA
Citazione:
J.B. Rangisetty et al., "PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA", PHARM BIO B, 69(1-2), 2001, pp. 261-267

Abstract

Psychoactive phenylisopropylamines can produce one or more of several different stimulus effects in animals. These effects are typified by the hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM), the central stimulant amphetamine, and by N-methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA), an agent whose actions are not yet well understood. The optical isomers of two phenylisopropylamines known to lack DOM and amphetamine-stimulus character, that is N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminobutane (MBDB) and 1-(3,4-dimethoxyphenyl)-2-aminopropane (3,4-DMA), were examined in rats trained to discriminate 1.25 mg/kg of PMMA from vehicle. The PMMA stimulus (ED50 = 0.4 mg/kg) generalized to all four agents: S(+)-MBDB (ED50 = 0.8 mg/kg), R(-)-MBDB (ED50 = 2.0 mg/kg), S(+)-3,4-DMA (ED50 = 2.6 mg/kg) andR(-)-3,4-DMA (ED50 = 3.9 mg/kg). The results show that these agents produce stimulus effects similar to those produced by PMMA. Both isomers of MBDB have been previously demonstrated to substitute for N-methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) in rats trained to discriminate MDMA from vehicle, but MBDB-trained animals failed to recognize DOM or amphetamine. Similar results were obtained with the 3,4-DMA optical isomers in the present investigation using rats trained to discriminate MDMA, DOM or (+)-amphetamine from vehicle; both isomers of 3,4-DMA substituted for an MDMA stimulus, but not for a DOM or amphetamine stimulus. Taken together, the evidence suggests that PMMA, S(+)-MBDB, R(-)MBDB, S(+)-3,4-DMA, R(-)-3,4-DMA, andS(+)-MDMA can produce common stimulus effects in rats. The present findings also better define the PMMA stimulus and the structural requirements necessary to produce this type of stimulus effect. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:24:48