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Titolo:
Effects of neonatal handling on nociceptin/orphanin FQ and opioid peptide levels in female rats
Autore:
Ploj, K; Roman, E; Bergstrom, L; Nylander, I;
Indirizzi:
Uppsala Univ, Dept Pharmaceut Sci, Div Pharmacol, S-75124 Uppsala, Sweden Uppsala Univ Uppsala Sweden S-75124 v Pharmacol, S-75124 Uppsala, Sweden
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1-2, volume: 69, anno: 2001,
pagine: 173 - 179
SICI:
0091-3057(200105/06)69:1-2<173:EONHON>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING FACTOR; PROTEIN-COUPLED RECEPTOR; ORPHANIN-FQ; PERIAQUEDUCTAL GRAY; ADRENOCORTICAL RESPONSES; GENE-EXPRESSION; CENTRAL NUCLEUS; STRESS; PITUITARY; BRAIN;
Keywords:
neonatal handling; stress; opioids; nociceptin/orphanin FQ;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Ploj, K Uppsala Univ, Dept Pharmaceut Sci, Div Pharmacol, Box 591, S-75124Uppsala, Sweden Uppsala Univ Box 591 Uppsala Sweden S-75124 75124 Uppsala, Sweden
Citazione:
K. Ploj et al., "Effects of neonatal handling on nociceptin/orphanin FQ and opioid peptide levels in female rats", PHARM BIO B, 69(1-2), 2001, pp. 173-179

Abstract

Animals exposed to short periods of handling during the critical period ofdevelopment, i.e., the first 21 days of life in rats, show attenuated neuroendocrine responses to stress in adult life. We have previously reported long-term changes in brain dynorphin (DYN) peptide levels in male Sprague-Dawley rats after neonatal handling. The purpose of this study was to investigate whether neonatal handling, 15-min individual separation from the mother during postnatal days 1-21, can induce long-term changes in DYNB, Met-enkephalin Arg(6)Phe(7) (MEAP) and nociceptin/orphanin FQ (N/OFQ) immunoreactive (ir) levels in female Sprague-Dawley rats. The peptides were measured inbrain and pituitary gland 2 months after the handling procedure. The results reveal that handled (H) rats had increased ir levels of N/OFQ, DYNB and MEAP in the periaqueductal gray (PAG) as compared to nonhandled (NH) controls. Furthermore, H rats had decreased ir levels of DYNB in the frontal cortex and in the amygdala. In contrast to previous findings in male rats, DYNBlevels were unaffected in areas related to the hypothalamo - pituitary - adrenal (HPA)-axis. The results indicate that a manipulation early in life can induce persistent neurochemical changes in the N/OFQ and opioid peptide system in female Sprague-Dawley rats. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:23:58