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Titolo:
The effects of pyridostigmine bromide, permethrin and DEET alone, or in combination, on fixed-ratio and fixed-interval behavior in male and female rats
Autore:
van Haaren, F; Haworth, SC; Bennett, SM; Cody, BA; Hoy, JB; Karlix, JL; Tebbett, IR;
Indirizzi:
Univ Florida, Dept Physiol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 Physiol, Gainesville, FL 32611 USA Univ Florida, Dept Pharm Practice, Gainesville, FL 32611 USA Univ FloridaGainesville FL USA 32611 Practice, Gainesville, FL 32611 USA Univ Florida, Dept Physiol Sci, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 siol Sci, Gainesville, FL 32611 USA
Titolo Testata:
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
fascicolo: 1-2, volume: 69, anno: 2001,
pagine: 23 - 33
SICI:
0091-3057(200105/06)69:1-2<23:TEOPBP>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALTER LOCOMOTOR BEHAVIOR; CENTRAL-NERVOUS-SYSTEM; RESPONSE ACQUISITION; N,N-DIETHYL-M-TOLUAMIDE DEET; PYRETHROID INSECTICIDES; WISTAR RATS; GULF-WAR; COCAINE; PERFORMANCE; TOXICITY;
Keywords:
Gulf War syndrome; pyridostigmine bromide; permethrin; N,N-diethyl-m-toluamide; fixed-ratio schedule; fixed-interval schedule; lever press; male rat; female rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: van Haaren, F Univ Florida, Dept Physiol, Gainesville, FL 32611 USA Univ Florida Gainesville FL USA 32611 esville, FL 32611 USA
Citazione:
F. van Haaren et al., "The effects of pyridostigmine bromide, permethrin and DEET alone, or in combination, on fixed-ratio and fixed-interval behavior in male and female rats", PHARM BIO B, 69(1-2), 2001, pp. 23-33

Abstract

Concurrent exposure to pyridostigmine bromide (PB), permethrin (PERM) and/or N,N-diethyl-m-toluamide (DEET) may have contributed to the development of a syndrome that appears to have afflicted military personnel who served during the Gulf War. The present experiment sought to evaluate the behavioral effects of these compounds alone, or in various combinations, in male andfemale rats. Subjects were exposed to a multiple fixed-ratio (FR) 50, fixed-interval (FI) 2-min schedule of reinforcement. PB dose-dependently decreased FR and FI response rates. FR responding was disrupted by lower doses and there were no differences between the sexes. PERM vehicle administration decreased response rates maintained by both schedules of reinforcement; this was offset by an increase in response rate after the administration of the intermediate dose of PERM. The highest dose of PERM decreased both FR andFI response rates. FR rates in male rats were more disrupted than those infemale rats. Only the highest dose of DEET decreased FR and FI response rates in male and female rats. FR rates were more disrupted in female rats than in male rats. Synergistic effects were only observed when FI response rates decreased in male rats upon exposure to half the low dose of PB with half the low dose of PERM or half the low dose of PB with half the low dose of DEET. The results of this experiment thus show that small doses of PB, PERM and DEET disrupt well-established, schedule-controlled behavior in male and female rats in a schedule- and gender-dependent manner; schedule-dependent and gender-dependent synergistic effects were also observed. The mechanism by which the compounds exert these behavioral effects remains to be determined. (C) 2001 Elsevier Science Inc. All rights reserved.

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Documento generato il 24/01/20 alle ore 12:16:54