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Titolo:
Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea
Autore:
Kreuter, A; Gambichler, T; Avermaete, A; Jansen, T; Hoffmann, M; Hoffmann, K; Altmeyer, P; von Kobyletzki, G; Bacharach-Buhles, M;
Indirizzi:
Ruhr Univ Bochum, Dept Dermatol, D-44791 Bochum, Germany Ruhr Univ BochumBochum Germany D-44791 ermatol, D-44791 Bochum, Germany
Titolo Testata:
PEDIATRIC DERMATOLOGY
fascicolo: 3, volume: 18, anno: 2001,
pagine: 241 - 245
SICI:
0736-8046(200105/06)18:3<241:CTWCOA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN DERMAL FIBROBLASTS; LOCALIZED SCLERODERMA; INTERSTITIAL COLLAGENASE; RADIATION-THERAPY; UVA IRRADIATION; PHOTOCHEMOTHERAPY; INDUCTION; CHILDREN; MMP-1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kreuter, A Ruhr Univ Bochum, Dept Dermatol, Gudrunstr 56, D-44791 Bochum, Germany Ruhr Univ Bochum Gudrunstr 56 Bochum Germany D-44791 , Germany
Citazione:
A. Kreuter et al., "Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea", PEDIAT DERM, 18(3), 2001, pp. 241-245

Abstract

Various therapies for morphea have been used with limited success, including ones with potentially hazardous side effects. When morphea occurs in childhood it may lead to progressive and long-lasting induration of the skin and subcutaneous tissue, growth retardation, and muscle atrophy. We report an open prospective study in which the efficacy of a combined treatment withcalcipotriol ointment and low-dose ultraviolet A1 (UVA1) phototherapy in childhood morphea was investigated, Nineteen children (mean age 8.5 years, range 3-13 years) with morphea were exposed to UVA1 (340-400 nm) phototherapy at a dose of 20 J/cm(2) four times a week for 10 weeks. Forty phototherapy sessions resulted in a cumulative dose of 800 J/cm(2) UVA1. In addition, calcipotriol ointment (0.005%) was applied twice a day, After in weeks, palpation and inspection showed a remarkable softening and repigmentation of formerly affected skin resulting in a highly significant (p < 0.001) decrease of the mean clinical score from 7.3 <plus/minus> 0.9 at the beginning to 2.4 +/- 0.9 (relative reduction 67.1%) at the end of combined therapy. Our results indicate that a combined therapy with calcipotriol ointment and low-dose UVA1 phototherapy is highly effective in childhood morphea, Further controlled studies are necessary to investigate whether this combined therapy is superior to UVA1 phototherapy alone.

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Documento generato il 14/11/18 alle ore 03:10:33