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Titolo:
Neuroinsular complex type I: Morphology and frequency in lean and genetically obese mice
Autore:
Persson-Sjogren, S;
Indirizzi:
Umea Univ, Sect Histol & Cell Biol, Dept Integrat Med Biol, SE-90187 Umea,Sweden Umea Univ Umea Sweden SE-90187 t Integrat Med Biol, SE-90187 Umea,Sweden
Titolo Testata:
PANCREAS
fascicolo: 1, volume: 23, anno: 2001,
pagine: 40 - 48
SICI:
0885-3177(200107)23:1<40:NCTIMA>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; TYROSINE-HYDROXYLASE; PANCREATIC GANGLIA; POSITIVE NEURONS; MOUSE PANCREAS; RAT PANCREAS; NERVE-FIBERS; INNERVATION; ISLET; IMMUNOREACTIVITIES;
Keywords:
nerve cells; islets; pancreas; ob/ob; acetylcholinesterase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Persson-Sjogren, S Umea Univ, Sect Histol & Cell Biol, Dept Integrat Med Biol, SE-90187 Umea,Sweden Umea Univ Umea Sweden SE-90187 , SE-90187 Umea,Sweden
Citazione:
S. Persson-Sjogren, "Neuroinsular complex type I: Morphology and frequency in lean and genetically obese mice", PANCREAS, 23(1), 2001, pp. 40-48

Abstract

No quantitative data are available regarding the rate of occurrence of nerve cells in association with endocrine pancreas (i.e., neuroinsular complexes type I [NICs]). or the difference in the distribution of NICs in normal and diabetic pancreas. In this report, pancreata from 20-day, 7-week, and 9-month-old lean (Ume (a) over circle +/?) and obese (Ume (a) over circle ob/ob) mice, as a ell as 10-month-old C57BL/6JBom and Ume (a) over circle ob/ob mice, were analyzed with regard to the association of acetylcholinesterase (AChE)-positive and protein gene product 9.5-like (PGP-LI) immunoreactive perikarya with islets, and nor in association with islets. NIC profiles were regularly observed, but were more frequent in the 20-day-old mice than in the 9-month-old +/? and ob/ob mice. The NIC profiles were often located close to a duct or blood vessel, significantly more frequently than islet profile in general. The data did not reveal any gross abnormality in ob/ob mice as regards the frequency of NICs or the number of AChE-positive and PGP-LI perikarya. However, the 9-month-old ob/ob mice demonstrated smaller clusters of perikarya in their NIC profiles as compared to the other mice, probably reflecting the fact that the perikarya were more widely spread out inthe hyperplastic islets of adult ob/ob mice. The results show that NICs are common and represent a substantial proportion of the islets in mouse pancreas, supporting the idea that they play a role in islet physiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:46:47