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Titolo:
L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in mice
Autore:
Dogrul, A; Yesilyurt, O; Isimer, A; Guzeldemir, ME;
Indirizzi:
Gulhane Mil Med Acad, Fac Med, Dept Med Pharmacol, TR-06018 Etlik Ankara, Turkey Gulhane Mil Med Acad Etlik Ankara Turkey TR-06018 8 Etlik Ankara, Turkey Gulhane Mil Med Acad, Fac Med, Dept Anesthesiol, TR-06018 Etlik Ankara, Turkey Gulhane Mil Med Acad Etlik Ankara Turkey TR-06018 8 Etlik Ankara, Turkey
Titolo Testata:
PAIN
fascicolo: 1, volume: 93, anno: 2001,
pagine: 61 - 68
SICI:
0304-3959(200107)93:1<61:LATCCB>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY AFFERENT NEURONS; ROOT GANGLION NEURONS; INTRATHECAL MORPHINE; RECEPTOR SUBTYPES; SENSORY NEURONS; RAT-BRAIN; CHOLECYSTOKININ-OCTAPEPTIDE; OPIATE RECEPTORS; OMEGA-CONOTOXIN; HIGH-THRESHOLD;
Keywords:
L-type voltage dependent Ca2+ channels; T-type voltage dependent Ca2+ channels; opioid receptor agonists; spinal cord; analgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Dogrul, A Gulhane Mil Med Acad, Dept Pharmacol, TR-06018 Etlik Ankara, Turkey Gulhane Mil Med Acad Etlik Ankara Turkey TR-06018 kara, Turkey
Citazione:
A. Dogrul et al., "L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective mu opioid agonist, but not to selective delta and kappa agonist at the level of the spinal cord in mice", PAIN, 93(1), 2001, pp. 61-68

Abstract

We examined the effects of amlodipine, a selective L-type voltage dependent Ca2+ channel (VDCC) blocker, and mibefradil. a selective T type VDCC blocker on the antinociceptive effects of morphine, and mu. delta and K opioid receptor selective agonist-induced antinociception at the spinal level. Intrathecally administered amlodipine and mibefradil potentiated morphine and [D-Ala(2). N mePhe(4), Gly-ol(5)] enkephalin (DAMGO)-induced antinociception by shifting their dose response curves to the left. However, intrathecally administered amlodipine and mibefradil did not affect [D-Pen(2), D-Pen(5)]enkephalin (DPDPE) and [trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrolidinyl)cyclohexyl] benzene acetamide (U-50. 488H)-induced antinociception. These data indicate that L-type and T-type VDCC blockers synergistically potentiate the analgesic effects of CL opioid receptor agonists, but not delta and K opioid receptor agonists. at the spinal level. Additionally, these data suggest that there is an important functional interaction between L-type and/ or T-type VDCC and mu opioid receptors in the process of analgesia. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

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Documento generato il 15/08/20 alle ore 19:15:25