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Titolo:
Antinociception by tricyclic antidepressants in the rat formalin test: differential effects on different behaviours following systemic and spinal administration
Autore:
Sawynok, J; Reid, A;
Indirizzi:
Dalhousie Univ, Dept Pharmacol, Halifax, NS B3H 4H7, Canada Dalhousie Univ Halifax NS Canada B3H 4H7 col, Halifax, NS B3H 4H7, Canada
Titolo Testata:
PAIN
fascicolo: 1, volume: 93, anno: 2001,
pagine: 51 - 59
SICI:
0304-3959(200107)93:1<51:ABTAIT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPATHIC PAIN; INFLAMMATORY EDEMA; JOINT INFLAMMATION; AMITRIPTYLINE; MODEL; MICE; FLUOXETINE; HYPERALGESIA; NOCICEPTION; DESIPRAMINE;
Keywords:
antidepressants; amitriptyline; formalin test; intrathecal; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
74
Recensione:
Indirizzi per estratti:
Indirizzo: Sawynok, J Dalhousie Univ, Dept Pharmacol, Halifax, NS B3H 4H7, Canada Dalhousie Univ Halifax NS Canada B3H 4H7 x, NS B3H 4H7, Canada
Citazione:
J. Sawynok e A. Reid, "Antinociception by tricyclic antidepressants in the rat formalin test: differential effects on different behaviours following systemic and spinal administration", PAIN, 93(1), 2001, pp. 51-59

Abstract

The present study (1) examined analgesic effects of systemically and spinally administered antidepressants (ADs) on phase 2 flinching and biting/licking behaviours in the rat formalin test, a model considered to be of greater relevance to clinical pain than acute threshold tests, and (2) determinedwhether motor or anti-inflammatory effects contributed to such actions. Systemic administration of amitriptyline (3-20 mg/ kg) produced a dose-related enhancement of flinching behaviours, while at the same time suppressing biting/licking behaviours. Imipramine (except for 20 mg/kg). nortriptyline. desipramine and fluoxetine had no significant effect on flinching behaviours. while producing a dose-related suppression of biting/licking behaviours. When administered spinally, either by acute lumbar puncture or via chronically implanted intrathecal cannulas, amitriptyline similarly augmented flinching behaviours. When given by lumbar puncture, amitriptyline suppressed biting/licking behaviours, but when intrathecal cannulas were used. this behaviour was not expressed in the formalin group. Other ADs also suppressed biting/licking behaviours without affecting flinching when given by lumbar puncture. Effects on paw volume were determined at the end of behavioural testing. Systemic administration of all ADs produced a dose-related reductionin paw volume. Spinal administration of nortriptyline by lumbar puncture also reduced paw volume, but for other agents, the reduction was not significant. Motor effects were noted qualitatively throughout these experiments, and considered in relation to nociceptive behaviours. These results indicate (a) a marked dissociation between the effects of systemic ADs on flinching and biting/licking behaviours in the formalin test, (b) spinal efficacy of ADs that essentially reproduces effects seen with systemic administrationwhen given by lumbar puncture, (c) a lack of causality between anti-inflammatory effects of ADs and their analgesic properties in the formalin test, and (d) a contribution of motor effects to analgesic actions at higher doses affecting biting/licking but nor flinching behaviours. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 23:50:17