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Titolo:
Role of calcium channels in the spinal transmission of nociceptive information from the mesentery
Autore:
Horvath, G; Brodacz, B; Holzer-Petsche, U;
Indirizzi:
Karl Franzens Univ Graz, Dept Expt & Clin Pharmacol, A-8010 Graz, Austria Karl Franzens Univ Graz Graz Austria A-8010 rmacol, A-8010 Graz, Austria
Titolo Testata:
PAIN
fascicolo: 1, volume: 93, anno: 2001,
pagine: 35 - 41
SICI:
0304-3959(200107)93:1<35:ROCCIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SENSORY NEURONS; N-TYPE; OMEGA-CONOTOXIN; P-TYPE; INDUCED ANTINOCICEPTION; VISCERAL NOCICEPTION; PEPTIDE RELEASE; INDUCED ANALGESIA; CORD NEURONS; KNEE-JOINT;
Keywords:
visceral nociception; spinal cord; verapamil; omega-conotoxin MVIIA; clonidine; morphine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Holzer-Petsche, U Karl Franzens Univ Graz, Dept Expt & Clin Pharmacol, Univ Pl 4, A-8010 Graz, Austria Karl Franzens Univ Graz Univ Pl 4 Graz Austria A-8010 a
Citazione:
G. Horvath et al., "Role of calcium channels in the spinal transmission of nociceptive information from the mesentery", PAIN, 93(1), 2001, pp. 35-41

Abstract

Opioids, alpha (2)-adrenoceptor agonists and blockers of voltage-gated calcium channels (VGCCs) have been attributed antinociceptive activity in various experimental set-ups. The present study tested the ability of morphine.clonidine and drugs acting at various VGCCss to inhibit the transmission of noxious stimuli from the mesentery at the level of the spinal cord, in rats under barbiturate anaesthesia traction of 20 g was applied to a bundle of mesenteric blood vessels. This caused immediate transient changes of meanarterial pressure that were taken as indication of nociception, Similar reflexes were elicited by applying 0.6% acetic acid to the same bundle of vessels. The reflexes were dose dependently reduced by intrathecal administration of morphine or clonidine, but were left unaltered by intrathecal administration of verapamil. Bay-K 8644 or omega -conotoxin MVIIA. Neither verapamil nor Bay-K 8644 influenced clonidine-induced analgesia. Conotoxin markedly enhanced the effectiveness of all doses of clonidine against both types of mesenteric stimuli. Verapamil, Bay-K 8643. as well as conotoxin reduced the ability of morphine to inhibit mechanically evoked reflexes, while there was no statistically significant effect in chemonociception. These data suggest that, at the spinal level, both morphine and clonidine are effectivedrugs to decrease the cardiovascular changes caused by acute mesenteric pain. In the dorsal spinal cord neither L-type nor N-type VGCCs are responsible on their own for the transmission of noxious stimuli from the mesentery. Inhibition of N-type channels markedly augments the action of clonidine. whereas blocking either VGCC seems to inhibit antinociceptive mechanisms induced by morphine. It is suggested that in patients the combined administration of clonidine with omega -conotoxin MVIIA might lead to effective pain control with reduced side effects. (C) 2001 International Association for the Study of Pain. Published by Elsevier Science B.V. All rights reservrd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 07:47:05