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Titolo:
Risk factors for squamous cell carcinoma of the oral cavity in young people - a comprehensive literature review
Autore:
Llewellyn, CD; Johnson, NW; Warnakulasuriya, KAAS;
Indirizzi:
Univ London Kings Coll, WHO Colaborating Ctr Oral Canc & Precanc, Guys Kings & St Thomas Sch Med & Dent, Dept Oral Med & Pathol,Inst Dent, London SE59RW, England Univ London Kings Coll London England SE5 9RW nt, London SE59RW, England
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 5, volume: 37, anno: 2001,
pagine: 401 - 418
SICI:
1368-8375(200107)37:5<401:RFFSCC>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; HUMAN-PAPILLOMAVIRUS DNA; FIRST-DEGREE RELATIVES; TUMOR-SUPPRESSOR GENE; LESS-THAN 40; PHARYNGEAL CANCER; UNITED-STATES; NECK-CANCER; INCREASING INCIDENCE; TONGUE CANCER;
Keywords:
review; oral cancer; young people; risk factors; epidemiology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
170
Recensione:
Indirizzi per estratti:
Indirizzo: Warnakulasuriya, KAAS Univ London Kings Coll, WHO Colaborating Ctr Oral Canc & Precanc, Guys Kings & St Thomas Sch Med & Dent, Dept Oral Med & Pathol,Inst Dent, Caldecot Rd, London SE5 9RW, England Univ London Kings Coll Caldecot Rd London England SE5 9RW
Citazione:
C.D. Llewellyn et al., "Risk factors for squamous cell carcinoma of the oral cavity in young people - a comprehensive literature review", ORAL ONCOL, 37(5), 2001, pp. 401-418

Abstract

There have been several reports of a rising incidence of oral cancer from many parts of the world. Although it is well known that oral cancer increases with age, recent trends for a rising incidence particularly relates to cancer of the tongue and mouth in young males. This review critically examines 46 publications devoted to oral cancer in the young adult. Most studies suggest that 4-6% of oral cancers now occur at ages younger than 40 years. Several studies examining risk factors for oral cancer in the young provideevidence that many younger patients have never smoked or consumed alcohol,which are recognised risk factors in older groups, or that duration of exposure may be too short for malignant transformation to occur. Information on many aspects of aetiology for this disease in the young implicating occupational, familial risk, immune deficits and virus infection are meagre. Thespectrum of genetic abnormality disclosed is similar to older patients, there is paucity of specific studies involving younger cohorts, but predisposition to genetic instability has been hypothesised as a likely cause. Conflicting evidence is also reported on the sex distribution and outcome compared with older patients. Much work is required to understand the caveats related to global demography, risk factors and their diagnostic and prognosticmarkers for this disease which might be considered a disease distinct fromthat occurring in older patients. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 01:11:56