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Titolo:
K-ras gene mutations in non-small cell lung cancer in Japanese
Autore:
Noda, N; Matsuzoe, D; Konno, T; Kawahara, K; Yamashita, Y; Shirakusa, T;
Indirizzi:
Fukuoka Univ, Sch Med, Dept Surg 2, Johnan Ku, Fukuoka City, Fukuoka 8140180, Japan Fukuoka Univ Fukuoka City Fukuoka Japan 8140180 y, Fukuoka 8140180, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 4, volume: 8, anno: 2001,
pagine: 889 - 892
SICI:
1021-335X(200107/08)8:4<889:KGMINC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ONCOGENE ACTIVATION; POINT MUTATION; P53 MUTATIONS; CLINICAL-SIGNIFICANCE; PROGNOSTIC VALUE; ADENOCARCINOMA; SMOKING; CARCINOGENESIS; ASSOCIATION; CARCINOMA;
Keywords:
lung carcinoma; K-ras; carcinogen; cigarette smoke; PCR-SSOP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Noda, N Fukuoka Univ, Sch Med, Dept Surg 2, Johnan Ku, 7-45-1 Nanakuma, Fukuoka City, Fukuoka 8140180, Japan Fukuoka Univ 7-45-1 Nanakuma Fukuoka City Fukuoka Japan 8140180 an
Citazione:
N. Noda et al., "K-ras gene mutations in non-small cell lung cancer in Japanese", ONCOL REP, 8(4), 2001, pp. 889-892

Abstract

To evaluate the association of mutations in the K-uns gene with the incidence of non-small cell lung cancer (NSCLC) in Japanese patients, 410 patients treated surgically were studied. DNA was extracted from frozen specimens,and polymerase chain reaction-sequence specific oligonucleotide probe (PCR-SSOP) hybridization assay was used to examine K-ras mutations in codons 12, 13 and 61. K-ras mutations were found in 33 patients (8.0%), rind all were smokers or ex-smokers. There were no significant differences in clinical or pathological stage between wild-type cases and mutant cases. The most frequently identified mutation was a G-T transversion (25/33, 75.8%) that resulted in the substitution of a glycine fur a cysteine or 3 valine. Previousstudies have shown that the majority of K-ras mutations among smokers are G -->T transversion. In our study, K-las mutations were found only in smokers, and there was a high frequency of G -->T transversions. A clear correlation exists between smoking and K-ras gene mutations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 11:18:52