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Titolo:
Relationship of p53 and Helicobacter pylori to clinicopathological features of human remnant stomach cancer after gastric surgery for primary gastriccancer
Autore:
Baba, M; Konno, H; Tanaka, T; Kamiya, K; Baba, S; Sugimura, H; Nakamura, S;
Indirizzi:
Hamamatsu Univ, Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Hamamatsu Univ, Sch Med, Dept Pathol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 4, volume: 8, anno: 2001,
pagine: 831 - 834
SICI:
1021-335X(200107/08)8:4<831:ROPAHP>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIC-ULCER DISEASE; CARCINOMA; OVEREXPRESSION; CARCINOGENESIS; INFECTION; RISK;
Keywords:
cancer of the remnant stomach; p53; Helicobacter pylori;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Baba, M Hamamatsu Univ, Sch Med, Dept Surg 2, 1-20-1 Handayama, Hamamatsu,Shizuoka 4313192, Japan Hamamatsu Univ 1-20-1 Handayama Hamamatsu ShizuokaJapan 4313192 n
Citazione:
M. Baba et al., "Relationship of p53 and Helicobacter pylori to clinicopathological features of human remnant stomach cancer after gastric surgery for primary gastriccancer", ONCOL REP, 8(4), 2001, pp. 831-834

Abstract

The purpose of this study was to evaluate the biological features of gastric cancer of the remnant stomach (RSC). Twenty-one patients underwent resection of the remnant stomach for RSC and were divided into two groups: the RSCB group consisted of 11 patients who underwent distal gastrectomy for benign disease and the RSCM group consisted of 10 patients who underwent gastrectomy for primary gastric cancer. The interval between primary surgery andthe appearance of gastric cancer in the remnant stomach was significantly shorter in the RSCM group than in the RSCB group. invasion of adjacent organs was more frequent in the RSCM group than in the RSCB group and the Ki-67labeling index of the tumors was significantly higher in the former group. Furthermore, p53 overexpression by tumors was almost twice as common in the RSCM group as in the RSCB group. Although there was no significant difference of the H. pylori positivity between the two groups, the rate for both groups was higher than reported in previous studies. Mutation of p53 may play an important role in the high proliferative activity of tumors in the RSCM group and I-I. pylori infection may be closely related to carcinogenesisin patients with RSC.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:03:03