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Titolo:
Expression of thrombospondin-1 inversely correlated with tumor vascularityand hematogenous metastasis in colon cancer
Autore:
Maeda, K; Nishiguchi, Y; Kang, SM; Yashiro, M; Onoda, N; Sawada, T; Ishikawa, T; Hirakawa, K;
Indirizzi:
Osaka City Univ, Sch Med, Dept Surg Oncol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ncol, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Dept Surg 1, Abeno Ku, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 rg 1, Abeno Ku, Osaka 5458585, Japan Osaka City Univ, Sch Med, Inst Geriatr & Med Sci, Dept Oncol, Osaka 5458585, Japan Osaka City Univ Osaka Japan 5458585 ci, Dept Oncol, Osaka 5458585, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 4, volume: 8, anno: 2001,
pagine: 763 - 766
SICI:
1021-335X(200107/08)8:4<763:EOTICW>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA EXPRESSION; BREAST-CARCINOMA; P53 ALTERATIONS; ANGIOGENESIS; GROWTH; DENSITY;
Keywords:
thrombospondin-1; colon cancer; tumor angiogenesis; hematogenous metastasis; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Maeda, K Osaka City Univ, Sch Med, Dept Surg Oncol, Abeno Ku, 1-4-3 Asahimachi, Osaka 5458585, Japan Osaka City Univ 1-4-3 Asahimachi Osaka Japan 5458585 8585, Japan
Citazione:
K. Maeda et al., "Expression of thrombospondin-1 inversely correlated with tumor vascularityand hematogenous metastasis in colon cancer", ONCOL REP, 8(4), 2001, pp. 763-766

Abstract

Solid tumors require neovascularization for growth and metastasis. Angiogenesis depends on the local balance between various molecules that induce and inhibit neovascularization. Thrombospondin-1 (TSP-1) is thought to be an antiangiogenic factor. In this study, we examined the correlation between expression of TSP-1 and tumor vascularity, and determined its prognostic significance in colon cancer. Microvessel density, determined by immunostaining for factor VIII-related antigen, was significantly higher in tumors that were TSP-1-negative. TSP-1 expression was inversely correlated with prognosis. Patients with TSP-1-negative tumors had a significantly worse prognosisthan did those with TSP-1-positive tumors, Frequency of hepatic recurrencewas significantly higher in patients with tumors that were TSP-1-negative. In conclusion, TSP-1 is an important negative regulator of tumor angiogenesis, and TSP-1 may be useful for predicting recurrence in patients with colon cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 01:02:49