Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Thymidine phosphorylase expression and effect of doxifluridine: A phase IIstudy
Autore:
Sadahiro, S; Otani, Y; Oya, K; Ike, H; Shimada, H; Yamaguchi, S; Hiki, Y; Fujita, H; Mitomi, T;
Indirizzi:
Tokai Univ, Sch Med, Dept Surg, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Kitasato Univ, Sch Med, Dept Surg Gastroenterol, East Hosp, Sagamihara, Kanagawa 2288520, Japan Kitasato Univ Sagamihara Kanagawa Japan 2288520 , Kanagawa 2288520, Japan St Marianna Univ, Sch Med, Dept Surg, Miyamae Ku, Kawasaki, Kanagawa 2168511, Japan St Marianna Univ Kawasaki Kanagawa Japan 2168511 Kanagawa 2168511, Japan Yokohama City Univ, Sch Med, Dept Surg 2, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360004 anagawa 2360004, Japan Tsurumi Univ, Dept Bacteriol, Sch Dent Med, Tsurumi Ku, Yokohama, Kanagawa2308501, Japan Tsurumi Univ Yokohama Kanagawa Japan 2308501 hama, Kanagawa2308501, Japan
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 4, volume: 8, anno: 2001,
pagine: 753 - 758
SICI:
1021-335X(200107/08)8:4<753:TPEAEO>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL GROWTH-FACTOR; RECURRENT BREAST-CANCER; ADVANCED GASTRIC-CANCER; COLORECTAL-CANCER; TUMOR-CELLS; 5'-DEOXY-5-FLUOROURIDINE; 5-FLUOROURACIL; CHEMOTHERAPY; CAPECITABINE; ANGIOGENESIS;
Keywords:
colorectal cancer; doxifluridine; capecitabine; thymidine phosphorylase; progression-free survival; survival; efficacy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sadahiro, S Tokai Univ, Sch Med, Dept Surg, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 gawa 2591193, Japan
Citazione:
S. Sadahiro et al., "Thymidine phosphorylase expression and effect of doxifluridine: A phase IIstudy", ONCOL REP, 8(4), 2001, pp. 753-758

Abstract

Doxifluridine (5 ' -DFUR), an active intermediate metabolite of capecitabine, is converted to 5-fluorouracil by thymidine phosphorylase (TP). We usedimmunohistochemical staining to investigate the relation between TP expression and 5 ' -DFUR effects in 40 patients with advanced/recurrent lung metastases from colorectal cancer. Cox regression analysis suggested that TP-positive cancer cells (risk ratio 3.72), were independent factors in survivalwhereas factors in progression-free survival were TP-positive cancer cells(2.93), and TF-positive stromal cells (0.24). It is suggested that TP expression in cancer cells and in stromal cells are opposite prognostic factorsin patients treated with 5 ' -DFUR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 10:48:42