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Titolo:
Effect of giant hepatomas on lymphocyte production and secretion of apoptosis-related proteins in the rat spleen
Autore:
Ben-Hur, H; Gurevich, P; Calmanovich, S; Gurevich, E; Zusman, I;
Indirizzi:
Hebrew Univ Jerusalem, Koret Sch Vet Med, Fac Agr Food & Environm Qual Sci, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel Kaplan Med Ctr, Dept Obstet & Gynecol, Rehovot, Israel Kaplan Med Ctr Rehovot Israel r, Dept Obstet & Gynecol, Rehovot, Israel Hebrew Univ Jerusalem, Rambam Med Ctr, Dept Neurol, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Rehovot Israel IL-76100 , IL-76100 Rehovot, Israel
Titolo Testata:
ONCOLOGY REPORTS
fascicolo: 4, volume: 8, anno: 2001,
pagine: 731 - 735
SICI:
1021-335X(200107/08)8:4<731:EOGHOL>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE; CARCINOGEN; ANTIBODIES; CELLS; TUMOR; VACCINATION; MARKERS; P53;
Keywords:
B cells; T cells; Fas; Fas ligand; giant tumors; IL-2; hepatoma; spleen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Zusman, I Hebrew Univ Jerusalem, Koret Sch Vet Med, Fac Agr Food & Environm Qual Sci, Box 12, IL-76100 Rehovot, Israel Hebrew Univ Jerusalem Box 12 Rehovot Israel IL-76100 ot, Israel
Citazione:
H. Ben-Hur et al., "Effect of giant hepatomas on lymphocyte production and secretion of apoptosis-related proteins in the rat spleen", ONCOL REP, 8(4), 2001, pp. 731-735

Abstract

The effect of extremely large hepatomas on splenic lymphoid elements and apoptosis-related proteins in rats were studied. Hepatoma cells were inoculated subcutaneously into 6-week-old rats, and 4 months later the quantities of T and B cells, macrophages, and cells positive for Fas, Fas ligand (FasL) and interleukin-2 (IL-2) were immunohistochemically evaluated in spleens. Grafting of hepatoma cells caused hyperplasia of the spleen and development of giant tumors that could reach one-third of the rat's body weight. A 7-fold increase in the weight of the spleen was mainly due to proliferation of B lymphocytes and macrophages in the red pulp, while the relative quantity of CD4(+) and CD8(+) T cells decreased. Extremely small amount of Fas(+) and FasL(+) lymphocytes were present in the marginal zone, the follicles, red pulp, and occasionally in the PALS. All the splenic zones were abundant with IL-2(+) cells, while macrophages and siderophages were present mainly in the red gulp and in the marginal zone of the white pulp. We suggest thatall these changes are compensatory processes of the host's lymphatic system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:08:56