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Titolo:
Models and methods for derivation of in vivo neuroreceptor parameters withPET and SPECT reversible radiotracers
Autore:
Slifstein, M; Laruelle, M;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Psychiat & Radiol, New York, NY 10032USA Columbia Univ Coll Phys & Surg New York NY USA 10032 ew York, NY 10032USA New York State Psychiat Inst, Dept Analyt Psychopharmacol, Div Funct BrainMapping, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 5, volume: 28, anno: 2001,
pagine: 595 - 608
SICI:
0969-8051(200107)28:5<595:MAMFDO>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON-EMISSION-TOMOGRAPHY; C-11 RACLOPRIDE BINDING; HUMAN-BRAIN; GRAPHICAL ANALYSIS; RECEPTOR-BINDING; BENZODIAZEPINE RECEPTORS; COMPARTMENTAL ANALYSIS; DOPAMINE TRANSPORTERS; CONTINUOUS-INFUSION; KINETIC-ANALYSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Slifstein, M Columbia Univ Coll Phys & Surg, Dept Psychiat & Radiol, 630 W168th St, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St New York NY USA 10032
Citazione:
M. Slifstein e M. Laruelle, "Models and methods for derivation of in vivo neuroreceptor parameters withPET and SPECT reversible radiotracers", NUCL MED BI, 28(5), 2001, pp. 595-608

Abstract

The science of quantitative analysis of PET and SPECT neuroreceptor imaging studies has grown considerably over the past decade. A number of methods have been proposed in which receptor parameter estimation results from fitting data to a model of the underlying kinetics of ligand uptake in the brain. These approaches have come to be collectively known as model-based methods and several have received widespread use. Here, we briefly review the most frequently used methods and examine their strengths and weaknesses. Kinetic modeling is the most direct implementation of the compartment models, but with some tracers accurate input function measurement and good compartment configuration identification can be difficult to obtain. Other methods were designed to overcome some particular vulnerability to error of classical kinetic modeling, but introduced new vulnerabilities in the process. Reference region methods obviate the need fur arterial plasma measurement, but are not as robust to violations of the underlying modeling assumptions as methods using the arterial input function. Graphical methods give estimates of V-T without the requirement of compartment model specification. but provide a biased estimator in the presence of statistical noise. True equilibrium methods are quite robust, but their use is limited to experiments with tracers that are suitable for constant infusion. In conclusion, there is no universally "best" method that is applicable to all neuroreceptor imaging studies, and carefully evaluation of model-based methods is required for each radiotracer. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:31:33