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Titolo:
[Tc-99m]MAG(3)-mannosyl-dextran: a receptor-binding radiopharmaceutical for sentinel node detection
Autore:
Vera, DR; Wallace, AM; Hoh, CK;
Indirizzi:
Univ Calif San Diego, Sch Med, Dept Radiol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 Radiol, La Jolla, CA 92093 USA Univ Calif San Diego, Sch Med, Dept Surg, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 t Surg, La Jolla, CA 92093 USA Univ Calif San Diego, Sch Med, UCSD Canc Ctr, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 nc Ctr, La Jolla, CA 92093 USA Univ Calif San Diego, Sch Med, Breast Care Serv, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 e Serv, La Jolla, CA 92093 USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 5, volume: 28, anno: 2001,
pagine: 493 - 498
SICI:
0969-8051(200107)28:5<493:[ARRF>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
BREAST-CANCER; LYMPH-NODE; GAMMA-PROBE; CHELATING AGENT; TECHNETIUM-99M; MELANOMA; PROTEIN; LECTIN; LOCALIZATION; MULTICENTER;
Keywords:
receptor-binding; technetium-99m; MAG(3); sentinel node detection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Vera, DR Univ Calif San Diego, Sch Med, Dept Radiol, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 a Jolla, CA 92093 USA
Citazione:
D.R. Vera et al., "[Tc-99m]MAG(3)-mannosyl-dextran: a receptor-binding radiopharmaceutical for sentinel node detection", NUCL MED BI, 28(5), 2001, pp. 493-498

Abstract

Technetium-99m-labeled benzoyl-mercaptoacetylglycyl-glycine-mannosyl-dextran ([Tc-99m] MAG(3)-mannosyl-dextran) is a receptor-binding radiotracer that binds to mannose-binding protein, a receptor expressed by recticuloendothelial tissue. This agent is composed of a 10.5-kilodalton molecule of dextran and multiple units of mannose, and benzoyl-mercaptoacetylglycylglycyl-glycine (BzMAG(3)). The tetraflorophenol-activated ester of BzMAG(3) and the imidate of thiomannose were used to covalently attach BzMAG(3) and mannose to an amino-terminated conjugate of dextran. This yielded a Is-kilodalton macromolecule consisting of 3 BzMAG(3) and 21 mannose units per dextran. Dynamic light scattering was used to measure a mean diameter of 5.5 nanometersfor BzMAG(3)-mannosyl-dextran and 0.28 microns for filtered Tc-99m sulfur colloid. A preliminary sentinel node detection study employing right fore and hind footpad injections of [Tc-99m]MAG(3)-mannosyl-dextran and left foreand hind footpad injections of filtered Tc-99m sulfur colloid demonstratedgreater sentinel lymph node uptake by the receptor-binding agent. (C) 2001Elsevier Science Inc. All rights reserved.

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Documento generato il 18/01/20 alle ore 13:05:23