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Titolo:
Cocaine decreases cell survival and inhibits neurite extension of rat locus coeruleus neurons
Autore:
Snow, DM; Smith, JD; Booze, RM; Welch, MA; Mactutus, CF;
Indirizzi:
Univ Kentucky, Dept Anat & Neurobiol, THRI, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 obiol, THRI, Lexington, KY 40536 USA Univ Kentucky, Grad Ctr Toxicol, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 Ctr Toxicol, Lexington, KY 40536 USA
Titolo Testata:
NEUROTOXICOLOGY AND TERATOLOGY
fascicolo: 3, volume: 23, anno: 2001,
pagine: 225 - 234
SICI:
0892-0362(200105/06)23:3<225:CDCSAI>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRENATAL COCAINE; TYROSINE-HYDROXYLASE; INTRAVENOUS COCAINE; DOPAMINE NEURONS; OXYGEN DELIVERY; GUIDANCE CUE; FETAL SHEEP; MOUSE-BRAIN; BLOOD-FLOW; EXPOSURE;
Keywords:
noradrenergic neurons; fibronectin; connectivity; prenatal cocaine; Long-Evans rats; tissue culture;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Snow, DM Univ Kentucky, Dept Anat & Neurobiol, THRI, Lexington, KY 40536 USA Univ Kentucky Lexington KY USA 40536 RI, Lexington, KY 40536 USA
Citazione:
D.M. Snow et al., "Cocaine decreases cell survival and inhibits neurite extension of rat locus coeruleus neurons", NEUROTOX T, 23(3), 2001, pp. 225-234

Abstract

Cocaine use during pregnancy is affiliated with neurobehavioral abnormalities in offspring that are associated with problems of attention. Given the putative role of the noradrenergic system in attentional processes, impairments in the noradrenergic system may underlie specific attentionally sensitive, neurobehavioral alterations. Recent data using a clinically relevant intravenous (iv) route of administration show that the norepinephrine cell bodies of the locus coeruleus (LC) are a primary target for in utero cocaineexposure. Cell survival and neurite outgrowth of LC neurons were studied using two paradigms: (1) in vitro, using a physiologically relevant concentration of cocaine, and (2) in vivo, using a clinically relevant intravenous rat model. Fetal cocaine exposure significantly decreased neuronal survivaltin vitro: P=.0001, n = 24; in vivo: P=.0337, n = 30), reduced neurite initiation tin vitro: P=.001, n =24; in vivo: P=.0169, n = 30), decreased the number of neurites elaborated (in vivo: P=.0031, n = 30), and reduced totalneurite length (in vivo: P=.0237, n = 30). The results of this novel approach toward an understanding of noradrenergic neurons as they respond to cocaine during development suggest that cocaine may affect behavior by negatively regulating neuronal pathfinding and synaptic connectivity. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:30:49