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Titolo:
Acute and chronic haloperidol treatments increase parkin mRNA levels in the rat brain
Autore:
Nakahara, T; Gotoh, L; Motomura, K; Kawanami, N; Ohta, E; Hirano, M; Uchimura, H;
Indirizzi:
Kyushu Univ, Fac Sci, Dept Chem, Fukuoka 8108560, Japan Kyushu Univ Fukuoka Japan 8108560 Sci, Dept Chem, Fukuoka 8108560, Japan Hizen Natl Mental Hosp, Ctr Emot & Behav Disorder, Saga 8420192, Japan Hizen Natl Mental Hosp Saga Japan 8420192 Disorder, Saga 8420192, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 306, anno: 2001,
pagine: 93 - 96
SICI:
0304-3940(20010622)306:1-2<93:AACHTI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
UBIQUITIN-PROTEIN LIGASE; JUVENILE PARKINSONISM; MESSENGER-RNA; SHOCK-PROTEIN; CELL-DEATH; CDCREL-1; CLONING; GENE;
Keywords:
parkin; haloperidol; Parkinson's disease; striatum; nucleus accumbens; substantia nigra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Nakahara, T Kyushu Univ, Fac Sci, Dept Chem, Fukuoka 8108560, Japan KyushuUniv Fukuoka Japan 8108560 em, Fukuoka 8108560, Japan
Citazione:
T. Nakahara et al., "Acute and chronic haloperidol treatments increase parkin mRNA levels in the rat brain", NEUROSCI L, 306(1-2), 2001, pp. 93-96

Abstract

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. We examined the effects of acute and chronic treatment with haloperidolon parkin mRNA expression in the rat brain by reverse transcription-polymerase chain reaction. Acute haloperidol treatment (2 mg/kg) increased parkinmRNA levels in the striatum and nucleus accumbens but not in the medial prefrontal cortex and substantia nigra. Four-week-treatment with haloperidol decanoate (25 mg eq/kg) produced a significant increase in parkin mRNA levels in the striatum without affecting to those in the medial prefrontal cortex, nucleus accumbens and substantia nigra. These results suggest that Parkin may be involved in the haloperidol-induced synaptic plasticity, since Parkin regulates the turnover of the synaptic protein, CDCrel-1. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/09/19 alle ore 22:47:56