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Titolo:
Distinct effect of orphanin FQ in nucleus raphe magnus and nucleus reticularis gigantocellularis on the rat tail flick reflex
Autore:
Yang, ZL; Zhang, YQ; Wu, GC;
Indirizzi:
Fudan Univ, Med Ctr, Dept Neurobiol, State Key Lab Med Neurobiol, Shanghai200032, Peoples R China Fudan Univ Shanghai Peoples R China 200032 anghai200032, Peoples R China
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 306, anno: 2001,
pagine: 69 - 72
SICI:
0304-3940(20010622)306:1-2<69:DEOOFI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROMEDIAL MEDULLA; ORL(1) RECEPTOR; NOCICEPTIN; PEPTIDE; CELLS;
Keywords:
orphanin FQ; nucleus raphe magnus; nucleus reticularis gigantocellularis; analgesia; hyperalgesia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Wu, GC Fudan Univ, Med Ctr, Dept Neurobiol, State Key Lab Med Neurobiol, 138 Yi Xue Yuan Rd, Shanghai 200032, Peoples R China Fudan Univ 138 Yi Xue Yuan Rd Shanghai Peoples R China 200032 hina
Citazione:
Z.L. Yang et al., "Distinct effect of orphanin FQ in nucleus raphe magnus and nucleus reticularis gigantocellularis on the rat tail flick reflex", NEUROSCI L, 306(1-2), 2001, pp. 69-72

Abstract

The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency(TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinjection of OFQ into the NRM significantly increased the TFL, whereas microinjection of OFQ into the NGC decreased the TFL, suggesting the analgesic effect of OFQ in the NRM and the hyperalgesic effect of OFQ in the NGC. As there are three classes of putative pain modulating neurons in the rostral ventromedial medulla (RVM), the hyperalgesic or analgesic effect of OFQ in the RVM might depend upon the different class of the neurons being acted. (C) 2001 Published by Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 07:10:25