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Titolo:
Mutant mice lacking the cholecystokinin(2) receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine
Autore:
Dauge, V; Beslot, F; Matsui, T; Roques, BP;
Indirizzi:
UFR Sci Pharmaceut & BIol, Dept Pharmacochim Mol & Struct, CNRS,UMR 8600, INSERM,U266, F-75270 Paris 06, France UFR Sci Pharmaceut & BIol Paris France 06 U266, F-75270 Paris 06, France Kobe Univ, Sch Med, Dept Med, Div 3,Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 3,Chuo Ku, Kobe, Hyogo 6500017, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 1-2, volume: 306, anno: 2001,
pagine: 41 - 44
SICI:
0304-3940(20010622)306:1-2<41:MMLTCR>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; MOTOR-ACTIVITY; CCK; ANTAGONISTS; ENKEPHALIN; NEURONS;
Keywords:
cholecystokinin(2) receptor-deficient mice; morphine; amphetamine; cocaine; dopamine antagonists; sensitization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Dauge, V UFR Sci Pharmaceut & BIol, Dept Pharmacochim Mol & Struct, CNRS,UMR 8600, INSERM,U266, 4 Ave Observ, F-75270 Paris 06, France UFR Sci Pharmaceut & BIol 4 Ave Observ Paris France 06 6, France
Citazione:
V. Dauge et al., "Mutant mice lacking the cholecystokinin(2) receptor show a dopamine-dependent hyperactivity and a behavioral sensitization to morphine", NEUROSCI L, 306(1-2), 2001, pp. 41-44

Abstract

Cholecystokinin(2) (CCK2) receptor-deficient mice were used to analyze thein vivo function of CCK2 receptor and especially the incidence of this gene invalidation on enkephalinergic and dopaminergic systems. Hyperlocomotor activity of CCK2 receptor-deficient mice was suppressed by a selective D2 antagonist but not by a D1 antagonist. Injection of amphetamine induced a hyperlocomotor activity in both groups of mice while mutant mice were less sensitive to cocaine. Administration of 6 mg/kg of morphine once every 2 daysfor 5 days significantly (P < 0.05) enhanced motor activity the last day compared to the first day, only in CCK2 receptor-deficient mice. These results emphasize the role of CCK2 receptors in counteracting the effects of dopaminergic systems and suggest that CCK2 receptor invalidation could lead toa slight behavioral sensitization. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:45:34