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Titolo:
Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation
Autore:
Negishi, H; Ikeda, K; Nara, Y; Yamori, Y;
Indirizzi:
Kyoto Univ, Grad Sch Human & Environm Sci, Kyoto, Japan Kyoto Univ KyotoJapan niv, Grad Sch Human & Environm Sci, Kyoto, Japan Univ E Asia, Grad Sch Integrated Sci & Art, Shimonoseki, Yamaguchi, Japan Univ E Asia Shimonoseki Yamaguchi Japan t, Shimonoseki, Yamaguchi, Japan
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 306, anno: 2001,
pagine: 206 - 208
SICI:
0304-3940(20010629)306:3<206:IHRITH>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL CEREBRAL-ISCHEMIA; OXIDATIVE DNA-DAMAGE; E PREVENTS APOPTOSIS; BRAIN ISCHEMIA; REPERFUSION; STRIATUM; NEURONS; ACTIVATION;
Keywords:
stroke-prone spontaneously hypertensive rats; transient ischemia; hydroxyl radicals; 2,3-dihydroxybenzoic acid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Negishi, H Int Prevent Nutr Med, Res Inst Prod Dev, Sakyo Ku, 15 ShimogamoMorimoto Cho, Kyoto 6060805, Japan Int Prevent Nutr Med 15 Shimogamo Morimoto Cho Kyoto Japan 6060805
Citazione:
H. Negishi et al., "Increased hydroxyl radicals in the hippocampus of stroke-prone spontaneously hypertensive rats during transient ischemia and recirculation", NEUROSCI L, 306(3), 2001, pp. 206-208

Abstract

It has been suggested that stroke-prone spontaneously hypertensive rats (SHRSP) show vulnerability to neuronal damage following transient ischemia. To observe the effect of hydroxyl radicals on neuronal damage in the hippocampus of SHRSP during ischemia and recirculation, we measured the levels of 2,3-dihydroxybenzoic acid (2,3-DHBA), as a biological marker of hydroxyl radicals in the hippocampus of SHRSP, by high pressure liquid chromatography-electrochemical detection. The production of hydroxyl radicals in the hippocampus during the first 20 min of recirculation was a peak in all intervals. The changes in 2,3-DHBA levels during ischemia and recirculation in SHRSPwere significantly higher than in Wistar-Kyoto rats. These results suggestthat neuronal damage following ischemia and recirculation is, in part, caused by the increase in hydroxyl radicals during ischemia and recirculation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 10:11:15