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Titolo:
Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampus
Autore:
Yau, JLW; Noble, J; Hibberd, C; Seckl, JR;
Indirizzi:
Western Gen Hosp, Mol Med Ctr, Mol Endocrinol Lab, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU dlothian, Scotland
Titolo Testata:
NEUROSCIENCE LETTERS
fascicolo: 3, volume: 306, anno: 2001,
pagine: 161 - 164
SICI:
0304-3940(20010629)306:3<161:SAOFAV>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; MINERALOCORTICOID RECEPTOR; GENE-EXPRESSION; THERAPEUTIC IMPLICATIONS; TYROSINE-HYDROXYLASE; ANTIDEPRESSANTS; SEROTONIN; BRAIN; BINDING; AXIS;
Keywords:
spatial memory; antidepressant; corticosterone; glucocorticoids; mineralocorticoid receptor; glucocorticoid receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Yau, JLW Western Gen Hosp, Mol Med Ctr, Mol Endocrinol Lab, Edinburgh EH4 2XU, Midlothian, Scotland Western Gen Hosp Edinburgh Midlothian Scotland EH4 2XU Scotland
Citazione:
J.L.W. Yau et al., "Short-term administration of fluoxetine and venlafaxine decreases corticosteroid receptor mRNA expression in the rat hippocampus", NEUROSCI L, 306(3), 2001, pp. 161-164

Abstract

Chronic treatment with antidepressant drugs (2 weeks or longer) increases corticosteroid receptor mRNA expression in the hippocampus and reduces hypothalamic-pituitary-adrenal axis activity in parallel with improving mood and neuroendocrine function. Earlier effects are less well documented. We examined the effects of short term (9 days) treatment with fluoxetine (10 mg/kg) and venlafaxine (10 mg/kg) on hippocampal mineralocorticoid receptor (MR) and glucocorticoid receptor(GR) mRNA expression and spatial memory in adult rats. In situ hybridization histochemistry showed that the antidepressants decreased MR mRNA expression in all hippocampal subregions (e.g. 45% decrease in CA1 with venlafaxine, P < 0.001), while GR mRNA expression was selectively reduced in the CA3 subregion. There was a trend for decreased plasma corticosterone levels following fluoxetine (50% fall, P = 0.07) and venlafaxine (30% fall, P = 0.18) but neither antidepressants affected spatial memory in the watermaze. Thus antidepressants can have complex and opposing actions on hippocampal corticosteroid receptor expression depending on the duration of treatment. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/07/18 alle ore 04:11:12