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Titolo:
Metabolic and electrophysiological alterations in an animal model of neocortical neuronal migration disorder
Autore:
Kraemer, M; Roth-Haerer, A; Bruehl, C; Luhmann, HJ; Witte, OW;
Indirizzi:
Univ Dusseldorf, Neurol Klin, D-40225 Dusseldorf, Germany Univ DusseldorfDusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany Univ Dusseldorf, Inst Neurophysiol, D-40225 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-40225 , D-40225 Dusseldorf, Germany
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2001 - 2006
SICI:
0959-4965(20010703)12:9<2001:MAEAIA>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL EPILEPTIC ACTIVITY; CORTICAL DEVELOPMENT; REGIONAL HYPOMETABOLISM; EXCITABILITY CHANGES; CEREBRAL-CORTEX; MALFORMATIONS; RAT; BRAIN; POLYMICROGYRIA; DYSGENESIS;
Keywords:
[C-14]deoxyglucose autoradiography; electrophysiology; epilepsy; field potential; freeze lesion; metabolism; migration disorder; polymicrogyria; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Witte, OW Univ Dusseldorf, Neurol Klin, Moorenstr 5, D-40225 Dusseldorf, Germany Univ Dusseldorf Moorenstr 5 Dusseldorf Germany D-40225 Germany
Citazione:
M. Kraemer et al., "Metabolic and electrophysiological alterations in an animal model of neocortical neuronal migration disorder", NEUROREPORT, 12(9), 2001, pp. 2001-2006

Abstract

Cortical migration disorders are a major cause for intractable epilepsy syndromes. High resolution MRI and PET are increasingly capable to identify cortical dysgenesis. In this study we used the rat freeze lesion model to investigate cortical morphological and functional changes in adult rats afterinduction of a cortical freeze lesion at postnatal day (p) 0. Autoradiographic measurements of basic cortical [C-14]-deoxyglucose metabolism showed asignificant reduction up to 1 mm lateral to the lesion but no remote changes. Electrophysiological in vitro recordings revealed a significant reduction in the amplitude of stimulus-evoked field potential responses recorded lateral to the lesion as compared to medial recording sites. Our data provide further evidence that spatially restricted developmental alterations of cortical morphology cause functional changes in surrounding and histologically normal areas that need to be considered for a better understanding of the resulting pathophysiology. NeuroReport 12:2001-2006 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 09:50:09