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Titolo:
Compartmentalized tau hyperphosphorylation and increased levels of kinasesin transgenic mice
Autore:
Gotz, J; Nitsch, RM;
Indirizzi:
Univ Zurich, Div Psychiat Res, CH-8008 Zurich, Switzerland Univ Zurich Zurich Switzerland CH-8008 Res, CH-8008 Zurich, Switzerland
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2007 - 2016
SICI:
0959-4965(20010703)12:9<2007:CTHAIL>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED HELICAL FILAMENTS; DEPENDENT MONOCLONAL-ANTIBODY; ALZHEIMERS-DISEASE; NEUROFIBRILLARY DEGENERATION; PHOSPHORYLATION SITES; MESSENGER-RNA; PROTEIN; DEMENTIA; BRAIN; CDK5;
Keywords:
Alzheimer's disease (AD); cyclin-dependent kinase-5; glycogen synthase kinase-3; neurodegeneration; neurofibrillary tangles (NFTs); tau;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Gotz, J Univ Zurich, Div Psychiat Res, August Forel Str 1, CH-8008 Zurich,Switzerland Univ Zurich August Forel Str 1 Zurich Switzerland CH-8008 zerland
Citazione:
J. Gotz e R.M. Nitsch, "Compartmentalized tau hyperphosphorylation and increased levels of kinasesin transgenic mice", NEUROREPORT, 12(9), 2001, pp. 2007-2016

Abstract

The formation of neurofibrillary tangles in Alzheimer's disease is preceded by a pretangle stage of hyperphosphorylated tau. To characterize pretangle tau in vivo, we correlated, in human tau transgenic mice, levels of kinases known to phosphorylate tau in vitro with the phosphorylation of tau at specific epitopes. Levels of cyclin-dependent kinase-5 were increased in axons of CAI pyramidal neurons, where tau was phosphorylated specifically at the AD2 epitope Ser396/Ser404. The 12E8 epitope serine262/serine356 and the AT180 epitope threonine231/serine235 were phosphorylated in dendrites, and colocalized with increased levels of glycogen synthase kinase-3. CAI neurons phosphorylated tau at more epitopes than dentate gyrus neurons, suggesting that tau phosphorylation is cell type-specific, a possible explanation for the spatial distribution of neurofibrillary tangles. NeuroReport 12:2007-2016 (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 08/04/20 alle ore 12:17:56