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Titolo:
Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat
Autore:
Cambonie, G; Kamenka, JM; Barbanel, G;
Indirizzi:
ENSCM, Med Chem Lab, CRBM, CNRS,UPR 1086, F-34296 Montpellier 5, France ENSCM Montpellier France 5 CNRS,UPR 1086, F-34296 Montpellier 5, France
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2035 - 2039
SICI:
0959-4965(20010703)12:9<2035:GIONHR>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; REGIONAL EXPRESSION; IN-VITRO; BRAIN; RECEPTORS; NEUROTOXICITY; TOXICITY; NEUROPROTECTION; STRIATUM; NEURONS;
Keywords:
development; free radicals; glutamate; metabotropic receptors; neonatal rats; neurotoxicity; NMDA receptors; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Barbanel, G ENSCM, Med Chem Lab, CRBM, CNRS,UPR 1086, 8 Rue Ecole Normale,F-34296 Montpellier 5, France ENSCM 8 Rue Ecole Normale Montpellier France 5 lier 5, France
Citazione:
G. Cambonie et al., "Glutamate inhibition of NMDA-induced hydroxyl radical release: an ontogenic study in rat", NEUROREPORT, 12(9), 2001, pp. 2035-2039

Abstract

Hydroxyl radicals ((OH)-O-.) are frequently associated with glutamate excitotoxicity and may be critical in the occurrence of perinatal brain damage. We thus investigated the mechanisms regulating the glutamate-induced release of toxic (OH)-O-. during development, using microdialysis and salicylateas an (OH)-O-. trap. Glutamate inhibited (OH)-O-. release until post-natalday 14, but stimulated this release from day 21 onwards. DHPG [(RS)-3,5-dihydroxyphenylglycine], a group-1 metabotropic glutamate receptor agonist, similarly reduced the (OH)-O-. release at day 14, but was ineffective afterwards. DHPG also completely blunted the tremendous NMDA-induced OH release at day 14 but not at day 21. Glutamate itself therefore tonically inhibited a possible free radical release through NMDA channel activation during early development. NeuroReport. 12:2035-2039 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 18:20:40