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Titolo:
Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1 beta
Autore:
Tanji, K; Imaizumi, T; Yoshida, H; Mori, F; Yoshimoto, M; Satoh, K; Wakabayashi, K;
Indirizzi:
Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Mol Biol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Vasc Biol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Taisho Pharmaceut Co Ltd, Med Res Labs, Mol Biol Lab, Omiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Omiya Saitama Japan 3308530 itama 3308530, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 1909 - 1912
SICI:
0959-4965(20010703)12:9<1909:EOAIAH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLIAL CYTOPLASMIC INCLUSIONS; MULTIPLE SYSTEM ATROPHY; CENTRAL-NERVOUS-SYSTEM; LEWY-BODY-DISEASE; A-BETA COMPONENT; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; NACP/ALPHA-SYNUCLEIN; MESSENGER-RNA; BRAIN;
Keywords:
astrocyte; cytokine; glial cell; inflammation; IL-I beta; alpha-synuclein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Tanji, K Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Mol Biol, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368562 62, Japan
Citazione:
K. Tanji et al., "Expression of alpha-synuclein in a human glioma cell line and its up-regulation by interleukin-1 beta", NEUROREPORT, 12(9), 2001, pp. 1909-1912

Abstract

Although alpha -synuclein is expressed primarily in neurons, it is a majorcomponent of oligodendroglial and astrocytic inclusions in several neurodegenerative diseases. Recent study has further demonstrated that alpha -synuclein is expressed in cultured rat oligodendrocytes. We determined whether alpha -synuclein might be expressed in astrocytic cells. alpha -Synuclein mRNA and protein were detected in U251 human astrocytic glioma cells and normal human astrocytes, and the levels were increased in the former, but not in the latter, by stimulation with interleukin-1 beta in a time- and concentration-dependent manner. Serum deprivation also led to an increase of alpha -synuclein mRNA and protein in U251 cells. Immunofluorescent staining confirmed the cell-associated alpha -synuclein. These findings suggest that human astrocytes can produce alpha -synuclein in culture and that certain inflammatory cytokines and cell stress increase alpha -synuclein expression. NeuroReport 12:1909-1912 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:53:06