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Titolo:
Glutamate transporters in the spinal cord of the wobbler mouse
Autore:
Bigini, P; Bastone, A; Mennini, T;
Indirizzi:
Mario Negri Inst Pharmacol Res, Lab Receptor Pharmacol, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Milan Italy I-20157 I-20157 Milan, Italy
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 1815 - 1820
SICI:
0959-4965(20010703)12:9<1815:GTITSC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; MOTONEURON DISEASE; MOTOR-NEURON; CHOLINE-ACETYLTRANSFERASE; IN-VITRO; BRAIN; ASTROCYTES; DEGENERATION; GLT-1; MODEL;
Keywords:
ChAT; EAACI; excitatory amino acids; GFAP; GLAST; GLT-I; motor neuron; plasma; wobbler mouse;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Mennini, T Mario Negri Inst Pharmacol Res, Lab Receptor Pharmacol, Via Eritrea 62, I-20157 Milan, Italy Mario Negri Inst Pharmacol Res Via Eritrea 62Milan Italy I-20157
Citazione:
P. Bigini et al., "Glutamate transporters in the spinal cord of the wobbler mouse", NEUROREPORT, 12(9), 2001, pp. 1815-1820

Abstract

We studied the role of glutamate excitotoxicity in motor neuron degeneration in the wobbler mouse (wr/wr), a model of amyotrophic lateral sclerosis and spinal muscular atrophies. Choline acetyltransferase (ChAT) activity wasdecreased in the cervical spinal cord and in the muscles innervated by nerves originating in this region of wobbler mice, bur, no differences were found in the lumbar spinal cord and in the hindleg muscles. Glial fibrillar acid protein (GFAP), a marker of reactive gliosis, was significantly higher in the cervical spinal cord of wobbler mice aged 4 weeks than in controls and the differences were more marked at 12 weeks; no differences were found in the lumbar spinal cord. In spite of this selective degeneration of motorneurons (resulting in strong decrease in the neuronal glutamate transporter EAAC1) and reactive gliosis in the cervical spinal cord. the levels of the glial glutamate transporter proteins GLT-1 and GLAST were similar in wobbler and control mice. Plasma concentrations of excitatory amino acids were no different at any time examined. Our results exclude the involvement of decrease in glutamate GLT-1 transporter in the motor neuron degeneration in wobbler mice. NeuroReport 12:1815-1820 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 13:02:15