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Titolo:
Regulation of chemokines and chemokine receptors after experimental closedhead injury
Autore:
Otto, VI; Stahel, PF; Rancan, M; Kariya, K; Shohami, E; Yatsiv, I; Eugster, HP; Kossmann, T; Trentz, O; Moreganti-Kossmann, MC;
Indirizzi:
Univ Zurich Hosp, Dept Surg, Div Res, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Surg, Div Trauma Surg, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Univ Zurich Hosp, Dept Med, Clin Immunol Sect, CH-8091 Zurich, SwitzerlandUniv Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland Hebrew Univ Jerusalem, Hadassah Med Sch, Dept Pharmacol, IL-91010 Jerusalem, Israel Hebrew Univ Jerusalem Jerusalem Israel IL-91010 -91010 Jerusalem, Israel
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 2059 - 2064
SICI:
0959-4965(20010703)12:9<2059:ROCACR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TRAUMATIC BRAIN INJURY; TUMOR-NECROSIS-FACTOR; ALZHEIMERS-DISEASE; EXPRESSION; ASTROCYTES; ALPHA; CCR5; RAT; INTERLEUKIN-8;
Keywords:
chemokines; chemokine receptors; cytokines; knockout mice; neuroinflammation; traumatic brain injury;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Stahel, PF Univ Zurich Hosp, Dept Surg, Div Res, CH-8091 Zurich, Switzerland Univ Zurich Hosp Zurich Switzerland CH-8091 rich, Switzerland
Citazione:
V.I. Otto et al., "Regulation of chemokines and chemokine receptors after experimental closedhead injury", NEUROREPORT, 12(9), 2001, pp. 2059-2064

Abstract

The expression of the chemokines macrophage inflammatory protein (MIP)-2 and MIP-1 alpha and of their receptors CXCR2 and CCR5 was assessed in wild type (WT) and TNF/lymphotoxin-alpha knockout (TNF/LT-alpha-/-) mice subjected to closed head injury (CHI). At 4 h after trauma intracerebral MIP-2 and MIP-1 alpha levels were increased in both groups with MIP-2 concentrations being significantly higher in WT than in TNF/LT-alpha-/- animals (p<0.05). Thereafter, MIP-2 production declined rapidly, whereas MIP-1<alpha> remained elevated for 7 days. Expression of CXCR2 was confined to astrocytes and increased dramatically within 24 h in both mouse types. Contrarily, CCR5 expression remained constitutively low and was mainly localized to microglia. These results show that after CHI, chemokines and their receptors are regulated differentially and with independent kinetics. NeuroReport 12:2059-2064(C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 02:35:49