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Titolo:
Delayed administration of NGF reverses nerve injury induced central alterations of primary afferents
Autore:
Siri, CR; Shortland, PJ; Grant, G; Olivius, NP;
Indirizzi:
Queen Mary Univ, St Bartholomews & Royal London Sch Med & Dent, Dept Neurosci, London E1 4NS, England Queen Mary Univ London England E1 4NS t Neurosci, London E1 4NS, England Karolinska Inst, Huddinge Hosp, Dept Surg Anaesthesiol Radiol & Orthoped, S-10401 Stockholm, Sweden Karolinska Inst Stockholm Sweden S-10401 oped, S-10401 Stockholm, Sweden Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ci, SE-17177 Stockholm, Sweden Karolinska Inst, Karolinska Hosp, ENT Dept, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 pt, SE-17176 Stockholm, Sweden
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 1899 - 1902
SICI:
0959-4965(20010703)12:9<1899:DAONRN>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY SENSORY NEURONS; RECEPTOR MESSENGER-RNA; ROOT GANGLION NEURONS; RAT DORSAL HORN; GROWTH-FACTOR; SCIATIC-NERVE; PERIPHERAL NEUROPATHY; LAMINA-II; AXOTOMY; ADULT;
Keywords:
neurotrophic factors; pain; plasticity; spinal cord; sprouting;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Shortland, PJ Queen Mary Univ, St Bartholomews & Royal London Sch Med & Dent, Dept Neurosci, Mile End Rd, London E1 4NS, England Queen Mary Univ MileEnd Rd London England E1 4NS , England
Citazione:
C.R. Siri et al., "Delayed administration of NGF reverses nerve injury induced central alterations of primary afferents", NEUROREPORT, 12(9), 2001, pp. 1899-1902

Abstract

We have examined whether delayed exogenous NGF administered to an axotomised peripheral nerve reverses the increased transganglionic choleragenoid (CTB) labelling in lamina II. Two, four, eight or 18 weeks after bilateral sciatic nerve section, NGF was applied unilaterally for an additional 2-week period to the transected nerve stump. The transganglionic choleragenoid labelling and substance P (SP) expression were determined and compared to the contralateral axotomised side in the spinal cord dorsal horn. Delayed NGF administration reversed the transganglionic choleragenoid labelling in lamina II when administered 2 or 18 weeks after the sciatic nerve lesion, but not at 4 or 8 weeks. There was also a clear recovery of SP on the axotomised,NGF-treated side 2 or 18 weeks after the sciatic nerve lesion, but not at the intermediate survival times. At the longer survival time, however, there was a recovery of SP regardless of NGF treatment. These results suggest that there is a critical window as to when NGF administration can be effective in reversing axotomy-induced changes in the spinal cord. NeuroReport 12:1899-1902 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:30:24