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Titolo:
Flecainide reverses neuropathic pain and suppresses ectopic nerve discharge in rats
Autore:
Ichimata, M; Kitano, T; Ikebe, H; Iwasaka, H; Noguchi, T;
Indirizzi:
Oita Med Univ, Dept Anesthesiol, Hasama, Oita 8795503, Japan Oita Med Univ Hasama Oita Japan 8795503 siol, Hasama, Oita 8795503, Japan
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: 1869 - 1873
SICI:
0959-4965(20010703)12:9<1869:FRNPAS>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS LIDOCAINE; SYSTEMIC LIDOCAINE; CARBAMAZEPINE; MEXILETINE; NEURALGIA; NEUROMAS; CANCER;
Keywords:
CCl model; flecainide; neuropathic pain; rats; sodium channel blocker;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ichimata, M Oita Med Univ, Dept Anesthesiol, 1-1 Idaigaoka, Hasama, Oita 8795503, Japan Oita Med Univ 1-1 Idaigaoka Hasama Oita Japan 8795503 3, Japan
Citazione:
M. Ichimata et al., "Flecainide reverses neuropathic pain and suppresses ectopic nerve discharge in rats", NEUROREPORT, 12(9), 2001, pp. 1869-1873

Abstract

We investigated effects of flecainide, a Class IC sodium channel blocker, in the rat chronic constrictive injury (CCI) and ectopic nerve discharge models. In the behavioral evaluation, 2, 6, and 12 mg/kg flecainide were intravenously given to the CCI model, and a dose-dependent analgesic effect wasshown on both thermal hyperalgesia and tactile allodynia. In the electrophysiological evaluation using the ectopic nerve discharge model produced by saphenous neurectomy, i.v. administration of 2, 6, and 12mg/kg flecainide suppressed spontaneous discharge at the peripheral nerve level in a dose-dependent fashion as with the behavioral evaluation, but flecainide did not affect nerve conduction at the dose of 12 mg/kg. NeuroReport 12: 1869-1873 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 03:14:38