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Titolo:
The Rb pathway in neurogenesis
Autore:
Ferguson, KL; Slack, RS;
Indirizzi:
Univ Ottawa, Neurosci Res Inst, Ottawa, ON K1H 8M5, Canada Univ Ottawa Ottawa ON Canada K1H 8M5 Res Inst, Ottawa, ON K1H 8M5, Canada
Titolo Testata:
NEUROREPORT
fascicolo: 9, volume: 12, anno: 2001,
pagine: A55 - A62
SICI:
0959-4965(20010703)12:9<A55:TRPIN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOOP-HELIX PROTEIN; RETINOBLASTOMA GENE-PRODUCT; TRANSCRIPTION FACTOR E2F; CELL-CYCLE REGULATION; S-PHASE ENTRY; DEVELOPING NERVOUS-SYSTEM; TUMOR-SUPPRESSOR GENE; HUMAN MYC PROMOTER; DNA-BINDING; POSTMITOTIC NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
179
Recensione:
Indirizzi per estratti:
Indirizzo: Slack, RS Univ Ottawa, Neurosci Res Inst, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada Univ Ottawa 451 Smyth Rd Ottawa ON Canada K1H 8M5 1H 8M5, Canada
Citazione:
K.L. Ferguson e R.S. Slack, "The Rb pathway in neurogenesis", NEUROREPORT, 12(9), 2001, pp. A55-A62

Abstract

Cell division during embryogenesis plays a crucial role in the formation of the nervous system. During this developmental process, proliferating neural precursor cells commit to a neuronal fate and, as a consequence, undergoterminal mitosis and adopt a neuronal phenotype. A key cell cycle regulator, the tumor suppressor protein, retinoblastoma (Rb), is involved in both terminal mitosis and neuronal differentiation. Neural development is a complex process involving cell proliferation, cell fate determination and differentiation, as well as programmed cell death. In this review, we will examine each of these processes in turn, focussing on the role of the Rb family proteins to examine their many influences on these events. NeuroReport 12:55-62 (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:45:41