Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice
Autore:
Szczypka, MS; Kwok, K; Brot, MD; Marck, BT; Matsumoto, AM; Donahue, BA; Palmiter, RD;
Indirizzi:
Univ Washington, Howard Hughes Med Inst, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ghes Med Inst, Seattle, WA 98195 USA Univ Washington, Dept Biochem, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biochem, Seattle, WA 98195 USA Univ Washington, Dept Orthodont, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Orthodont, Seattle, WA 98195 USA Vet Adm Med Ctr, Gerontol Res Educ & Clin Ctr, Seattle, WA 98108 USA Vet Adm Med Ctr Seattle WA USA 98108 uc & Clin Ctr, Seattle, WA 98108 USA Dept Med, Seattle, WA 98108 USA Dept Med Seattle WA USA 98108Dept Med, Seattle, WA 98108 USA Cell Genesys Inc, Dept Preclin Biol, Foster City, CA 94404 USA Cell Genesys Inc Foster City CA USA 94404 Biol, Foster City, CA 94404 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 30, anno: 2001,
pagine: 819 - 828
SICI:
0896-6273(200106)30:3<819:DPITCP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS-ACCUMBENS; TYROSINE-HYDROXYLASE; PARKINSONS-DISEASE; BASAL GANGLIA; FOOD-INTAKE; BEHAVIOR; REWARD; RAT; REINFORCEMENT; SHELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Palmiter, RD Univ Washington, Howard Hughes Med Inst, Box 357370, Seattle,WA 98195 USA Univ Washington Box 357370 Seattle WA USA 98195 WA 98195 USA
Citazione:
M.S. Szczypka et al., "Dopamine production in the caudate putamen restores feeding in dopamine-deficient mice", NEURON, 30(3), 2001, pp. 819-828

Abstract

Dopamine-deficient (DD) mice cannot synthesize dopamine (DA) in dopaminergic neurons due to selective inactivation of the tyrosine hydroxylase gene in those neurons. These mice become hypoactive and hypophagic and die of starvation by 4 weeks of age. We used gene therapy to ascertain where DA replacement in the brain restores feeding and other behaviors in DD mice. Restoration of DA production within the caudate putamen restores feeding on regular chow and nest-building behavior, whereas restoration of DA production inthe nucleus accumbens restores exploratory behavior. Replacement of DA to either region restores preference for sucrose or a palatable diet without fully rescuing coordination or initiation of movement. These data suggest that a fundamental difference exists between feeding for sustenance and the ability to prefer rewarding substances.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 13:38:23