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Titolo:
Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac
Autore:
Rosay, P; Armstrong, JD; Wang, ZS; Kaiser, K;
Indirizzi:
Univ Glasgow, IBLS Div Mol Genet, Glasgow G12 8QQ, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G12 8QQ ow G12 8QQ, Lanark, Scotland Neuropa Ltd, Glasgow G11 6NU, Lanark, Scotland Neuropa Ltd Glasgow LanarkScotland G11 6NU gow G11 6NU, Lanark, Scotland
Titolo Testata:
NEURON
fascicolo: 3, volume: 30, anno: 2001,
pagine: 759 - 770
SICI:
0896-6273(200106)30:3<759:SNAITD>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECTIFIER POTASSIUM CURRENT; MUSHROOM BODY NEURONS; LONG-TERM-MEMORY; GENE-EXPRESSION; PHARMACOLOGICAL ANALYSIS; ACETYLCHOLINE-RECEPTORS; CORPORA PEDUNCULATA; CHANNEL BLOCKERS; CORTICAL-NEURONS; IONIC CURRENTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Kaiser, K Univ Glasgow, IBLS Div Mol Genet, Anderson Coll Complex, GlasgowG12 8QQ, Lanark, Scotland Univ Glasgow Anderson Coll Complex Glasgow Lanark Scotland G12 8QQ
Citazione:
P. Rosay et al., "Synchronized neural activity in the Drosophila memory centers and its modulation by amnesiac", NEURON, 30(3), 2001, pp. 759-770

Abstract

The mushroom bodies are key features of the brain circuitry for insect associative learning, especially when evoked by olfactory cues. Mushroom bodies are also notable for the close-packed parallel architecture of their manyintrinsic neuronal elements, known as Kenyon cells. Here, we report that Kenyon cells of adult Drosophila exhibit synchronous oscillation of intracellular calcium concentration, with a mean period of approximately 4 min. Robust oscillation within a dissected brain persists for hours in insect saline and is strongly modulated in amplitude by the product(s) of the memory consolidation gene, amnesiac. It is also sensitive to pharmacological agents specific for several classes of ion channel and for acetylcholine and GABA receptors. A role in memory consolidation involving transcriptionally mediated synaptic strengthening is proposed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:05:52